{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:04:22Z","timestamp":1791194662892,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T00:00:00Z","timestamp":1180137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> Liver damage due to facultative hepatotoxins is scarcely foreseeable. We evaluated the prevalence of acute drug\u2010induced liver injury (DILI) in a specific setting, assessing eventual interactions with pre\u2010existing hepatic illnesses.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The research was carried out in an Italian tertiary care hospital, by analyzing 248 patients with non\u2010advanced liver disease, divided into two well\u2010matched groups: 174 patients (median age 53, 94 females) with hepatitis C virus\u2010related chronic hepatitis; and 74 (median age 55, 39 females) with non\u2010alcoholic fatty liver disease (NAFLD).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Six patients (2.4% of the whole population) belonging to the NAFLD group (\u03c7<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b2\"><jats:sup>2<\/jats:sup><\/jats:ext-link>\u2010test, <jats:italic>P<\/jats:italic>\u2003=\u20030.004) suffered from acute hepatoxicity related to the following drugs, that is antihypertensive, acting on platelet aggregation, antimicrobial, non\u2010steroidal anti\u2010inflammatory and proton pump inhibitor. The NAFLD presence was an independent risk factor in determining drug\u2010related acute hepatitis, with an odds ratio of 3.95 (95% confidence intervals: 11.48\u20131.35). Central obesity was relevant in every patient with acute toxicity. Alcohol consumption and drug association did not influence the acute drug\u2010induced liver damage.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> NAFLD conveys a nearly fourfold increase of DILI risk in obese middle\u2010aged patients. NAFLD, characterized by mitochondrial dysfunction, could predispose to drug\u2010induced hepatotoxicity that probably shares the same pathophysiological mechanism.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2007.00072.x","type":"journal-article","created":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T11:06:07Z","timestamp":1180177567000},"page":"410-415","source":"Crossref","is-referenced-by-count":145,"title":["A prospective study of acute drug\u2010induced liver injury in patients suffering from non\u2010alcoholic fatty liver 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