{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:12:46Z","timestamp":1769047966910,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,7,4]],"date-time":"2007-07-04T00:00:00Z","timestamp":1183507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold>Serum antinuclear antibodies (ANA) are occasionally noted in patients with non\u2010alcoholic steatohepatitis (NASH). We examined the significance of ANA in NASH.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>We compared clinicopathological features in patients with ANA\u2010positive NASH (<jats:italic>n<\/jats:italic>\u2003=\u200335) and ANA\u2010negative NASH (<jats:italic>n<\/jats:italic>\u2003=\u200336). Inflammatory cell profiles and the distribution of oxidative stress markers were also examined immunohistochemically.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>ANA\u2010positive NASH was significantly associated with female gender (<jats:italic>P<\/jats:italic>\u2003=\u20030.005), high degree of portal inflammation (<jats:italic>P<\/jats:italic>\u2003=\u20030.039), interface activity (<jats:italic>P<\/jats:italic>\u2003=\u20030.036) and hepatocellular ballooning (<jats:italic>P<\/jats:italic>\u2003=\u20030.0008). In addition, ANA of high titer (320\u2010fold or more) was significantly associated with the histological grade and stage of NASH (<jats:italic>P<\/jats:italic>\u2003=\u20030.02). The degree of steatosis wais rather mild in the high\u2010titer ANA group(<jats:italic>P<\/jats:italic>\u2003=\u20030.01). The analysis of inflammatory cell profiles revealed that CD3\u2010positive T cells were predominant and plasma cells were rather few in the portal area and hepatic lobules in both ANA\u2010positive and ANA\u2010negative groups. There was no difference in the distribution of oxidative stress markers between ANA\u2010positive and ANA\u2010negative groups.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>These findings suggest that the presence of ANA may be related to the progression of NASH and that a different type of autoimmune mechanism may be involved in the pathogenesis of NASH with ANA, compared to the pathogenesis of autoimmune hepatitis.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2007.00150.x","type":"journal-article","created":{"date-parts":[[2007,7,4]],"date-time":"2007-07-04T23:45:38Z","timestamp":1183592738000},"page":"923-931","source":"Crossref","is-referenced-by-count":41,"title":["Clinicopathological significance of antinuclear antibodies in non\u2010alcoholic 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