{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:39:15Z","timestamp":1793741955357,"version":"4.6.1"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,7,4]],"date-time":"2007-07-04T00:00:00Z","timestamp":1183507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Lipoxins (LX) are trihydroxytetraene\u2010containing eicosanoids that display unique anti\u2010inflammatory and pro\u2010resolving actions during various inflammatory conditions, but the pathophysiological significance of LX in liver disorders remains unknown.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In the present study, we used a murine model of carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced acute liver injury to investigate the effects of LX on the progression of acute liver injury.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The results indicated that the lipoxin A<jats:sub>4<\/jats:sub> receptor (ALX) was upregulated after giving CCl<jats:sub>4<\/jats:sub>. BML\u2010111, a commercially available ALX agonist, effectively protected the liver from CCl<jats:sub>4<\/jats:sub>\u2010induced injury as evidenced by decreased serum aminotransferase (ALT, AST) levels and improved histological damage. The dampened liver injury was accompanied byreduced malondialdehyde (MDA) content in liver homogenates and decreased concentration of tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) in the serum. Most interestingly, BML\u2010111 markedly upregulated hepatic heme oxygenase\u20101 (HO\u20101) expression in CCl<jats:sub>4<\/jats:sub>\u2010treated mice, which might provide antioxidative activities in the liver.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These data indicate that ALX agonist BML\u2010111 plays a critical protective role in CCl<jats:sub>4<\/jats:sub>\u2010induced acute liver injury through limiting the inflammatory response and promoting antioxidative protein expression.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2007.00154.x","type":"journal-article","created":{"date-parts":[[2007,7,5]],"date-time":"2007-07-05T01:48:09Z","timestamp":1183600089000},"page":"948-956","source":"Crossref","is-referenced-by-count":38,"title":["Protective effects of BML\u2010111, a lipoxin A<sub>4<\/sub> receptor agonist, on carbon tetrachloride\u2010induced liver injury in mice"],"prefix":"10.1111","volume":"37","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duyun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1383"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2820055"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7016"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00106.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404722101"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000119962.69573.CC"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0416fje"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"C870","DOI":"10.1152\/ajpcell.1999.277.5.C870","article-title":"Hepatocytes are a rich source of novel aspirin\u2010triggered 15\u2010epi\u2010lipoxin A (4)","volume":"277","author":"Titos E","year":"1999","journal-title":"Am J Physiol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1204747"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00157-4"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(89)90050-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050649"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.0316"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202296999"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)81354-3"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.3.4"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.9.1693"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.1.253"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0770com"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.5.2688"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000032417.73640.72"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1878"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000015795.74094.91"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.12.1923"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1392"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90149-3"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2000.9133"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.12.6266"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(98)00110-6"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1534-3"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2000.9133"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.5.2772"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00379.x"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1999.tb02268.x"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00045.2005"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00230.2005"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2005"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.08.121"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612033453730"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043365080"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00444-1"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.08.014"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.8.903"},{"key":"e_1_2_6_45_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1160\/TH06-06-0315","article-title":"Aspirin\u2010triggered lipoxin A4 blocks reactive oxygen species generation in endothelial cells: a novel antioxidative mechanism","volume":"97","author":"Nascimento\u2010Silva V","year":"2007","journal-title":"Thromb Haemost"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400102"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1056"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1872-034X.2007.00154.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1872-034X.2007.00154.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T16:14:52Z","timestamp":1697386492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1872-034X.2007.00154.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,4]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1111\/j.1872-034X.2007.00154.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1872-034x.2007.00154.x","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,4]]}}}