{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:50:55Z","timestamp":1792147855619,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T00:00:00Z","timestamp":1191974400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>Autoimmune pancreatitis is a unique form of chronic pancreatitis characterized by irregular narrowing of the pancreatic duct, pancreatic swelling, and a favorable response to corticosteroids, in which the autoimmune mechanism is postulated in the pathogenesis. High serum immunoglobulin (Ig)G4 concentrations and various types of extrapancreatic involvement are prominent features of this disease. Sclerosing cholangitis is a major extrapancreatic lesion of autoimmune pancreatitis that has been regarded as primary sclerosing cholangitis (PSC) complicating chronic pancreatitis. Because sclerosing cholangitis associated with autoimmune pancreatitis (SC\u2010AIP) also favorably responds to corticosteroid therapy, it should be differentiated from PSC. Useful points regarding the differentiation between SC\u2010AIP and PSC are as follows: (i) PSC occurs in younger and SC\u2010AIP in older individuals; (ii) obstructive jaundice is more frequently seen in SC\u2010AIP; (iii) PSC is complicated with inflammatory bowel disease, whereas SC\u2010AIP is complicated with so called extrapancreatic lesions of AIP; (iv) high serum IgG4 concentrations are frequently seen in SC\u2010AIP; (v) a cholangiogram may differentiate the two conditions to some extent; (vi) abundant IgG4\u2010bearing plasma cell infiltration is seen in SC\u2010AIP; and (vii) steroid therapy is effective for SC\u2010AIP. IgG4\u2010related sclerosing cholangitis without pancreatic lesion may be a metachronous phenotype of SC\u2010AIP, and also should be differentiated from PSC. The pathogenesis of AIP and SC\u2010AIP remains unclear. The complement activation system of the classical pathway may be contributing in some cases.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2007.00235.x","type":"journal-article","created":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T03:22:56Z","timestamp":1192072976000},"source":"Crossref","is-referenced-by-count":28,"title":["Sclerosing cholangitis associated with autoimmune pancreatitis"],"prefix":"10.1111","volume":"37","author":[{"given":"Shigeyuki","family":"Kawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Hamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeji","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendo","family":"Kiyosawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,10]]},"reference":[{"key":"e_1_2_11_2_2","first-page":"640","article-title":"An unusual type of chronic pancreatitis showing diffuse irregular narrowing of the entire main pancreatic duct on ERCP \u2013 a report of four cases (abstract)","volume":"24","author":"Toki F","year":"1992","journal-title":"Endoscopy"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02285209"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.SLA.0000071516.54864.C1"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441005"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08359-9"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90087-6"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012595961-2\/50059-7"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1908-9"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000202950.02988.07"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2044-x"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1868-0"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-11-200412070-00033"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.5.683"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2703-9"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200307000-00003"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg477"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.1752"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00603-0"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.110452"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016452813815"},{"key":"e_1_2_11_22_2","first-page":"625","article-title":"Atypical primary sclerosing cholangitis cases associated with unusual pancreatitis","volume":"48","author":"Nakazawa T","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)02229-1"},{"key":"e_1_2_11_24_2","first-page":"20","article-title":"Clinical differences between primary sclerosing cholangitis and sclerosing cholangitis with autoimmune pancreatitis","volume":"30","author":"Nakazawa T","year":"2005","journal-title":"Pancreas"},{"key":"e_1_2_11_25_2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00535-002-1108-1","article-title":"Autoimmune pancreatitis and multiple bile duct strictures treated effectively with steroid","volume":"38","author":"Kojima E","year":"2003","journal-title":"J Gastroenterol"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(03)00221-0"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1223-7"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000136449.37936.6c"},{"key":"e_1_2_11_29_2","first-page":"31","article-title":"Long\u2010term prognosis of duct\u2010narrowing chronic pancreatitis: strategy for steroid treatment","volume":"30","author":"Wakabayashi T","year":"2005","journal-title":"Pancreas"},{"key":"e_1_2_11_30_2","first-page":"76","article-title":"Biliary tract involvement in autoimmune pancreatitis","volume":"30","author":"Nishino T","year":"2005","journal-title":"Pancreas"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2005.01845.x"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000175178.85786.1d"},{"key":"e_1_2_11_33_2","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S0016-5085(82)80125-X","article-title":"The pancreas in primary biliary cirrhosis and primary sclerosing cholangitis","volume":"83","author":"Epstein O","year":"1982","journal-title":"Gastroenterology"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01213311"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04075.x"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000202941.85955.07"},{"key":"e_1_2_11_37_2","first-page":"691","article-title":"Elevated serum IgG4 concentration in patients with primary sclerosing cholangitis","volume":"102","author":"Mendes FD","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_11_38_2","unstructured":"LindorKD LaRussoNF.Primary sclerosing cholangitis. In:SchiffER SorrellMF MaddreyWC eds. Philadelphia PA:Lippincott William and Wilikins 2003;673\u201384."},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01040_8.x"},{"key":"e_1_2_11_40_2","first-page":"269","article-title":"IgG4 negative sclerosing cholangitis associated with autoimmune pancreatitis","volume":"10","author":"Sewkani A","year":"2005","journal-title":"JOP"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.11.031"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200308000-00009"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2004.03.006"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(05)00561-4"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33022"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.095059"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000188308.75043.e4"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1872-034X.2007.00235.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1872-034X.2007.00235.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T04:38:55Z","timestamp":1694493535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1872-034X.2007.00235.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":46,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1872-034X.2007.00235.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1872-034x.2007.00235.x","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}