{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:15:18Z","timestamp":1694582118333},"reference-count":6,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T00:00:00Z","timestamp":1191974400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Autoreactive T cells that proliferate in response to autoantigens are found in both autoimmune diseases and controls but have important qualitative differences in relative activation states, costimulation signal requirements and pathogenetic significance.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> To understand the differences between autoreactive T cells in PBC versus controls, we have developed autoreactive T\u2010cell clones (TCC) from patients with PBC and healthy controls, and have used a peptide corresponding to the CD4 major autoantigen (Ag) to define the relative proliferative response. Peripheral blood mononuclear cells (PBMC) from PBC respond to the Ag in a costimulation\u2010independent manner, but PBMC from controls respond to the Ag in a costimulation\u2010dependent manner. Next, we established nine autoreactive TCC from patients with PBC and eight from healthy controls.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Among 17 TCC, eight were the costimulation\u2010dependent type and nine were independent. In addition, costimulation\u2010dependent autoreactive TCC became anergic after stimulation in the presence of APC that did not provide costimulatory signals. Finally, we observed that anergic TCC exhibit regulatory functions.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In the case of regulatory dendritic cells, we could not induce TCC anergy. On the other hand, when using peptide analog in a costimulation\u2010deficient manner, we could induce TCC anergy, even though these TCC were costimulation independent.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2007.00239.x","type":"journal-article","created":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T03:22:56Z","timestamp":1192072976000},"source":"Crossref","is-referenced-by-count":1,"title":["Autoreactive T\u2010cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory"],"prefix":"10.1111","volume":"37","author":[{"given":"Shinji","family":"Shimoda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Ishibashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.3.1532"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1528"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214114"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.5.1835"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.07.013"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.05.056"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1872-034X.2007.00239.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1872-034X.2007.00239.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T04:38:37Z","timestamp":1694493517000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1872-034X.2007.00239.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":6,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1872-034X.2007.00239.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1872-034x.2007.00239.x","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}