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We found that there are two different types of progression in PBC; one is a hepatic failure\u2010type progression which is represented by positive anti\u2010gp210 antibodies and the other is a portalhypertension\u2010type progression which is represented by positive anticentromere antibodies. We discuss the predictive role of these ANA in the long\u2010term outcome of PBC and the mechanisms by which two different PBC progression types occur based on molecular mimicry and aberrant expression of nuclear antigens.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2007.00244.x","type":"journal-article","created":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T03:22:56Z","timestamp":1192072976000},"source":"Crossref","is-referenced-by-count":24,"title":["Predictive role of anti\u2010gp210 and anticentromere antibodies in long\u2010term outcome of primary biliary 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