{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,15]],"date-time":"2026-11-15T03:45:55Z","timestamp":1794714355402,"version":"4.9.1"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T00:00:00Z","timestamp":1215475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> Chemotherapy for advanced hepatocellular carcinoma (HCC) patients with hypersplenism is generally unsatisfactory, as a lower\u2010dose therapy is usually administered. Splenectomy may represent a better approach to overcoming the complication due to hypersplenism in patients with advanced HCC. This retrospective study was conducted to evaluate whether HCC patients who undergo splenectomy show improved prognosis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We examined 34 HCC patients. Twenty\u2010two had thrombocytopenia and\/or leucopenia and underwent laparoscopic splenectomy. The completion rate of full\u2010dose drug regimens, the response rate, the toxicity of chemotherapy and the cumulative survival rate were compared between the splenectomy and non\u2010splenectomy groups.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The response rate and the cumulative survival rate in the splenectomy group were significantly better than that in the non\u2010splenectomy group.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Splenectomy is an efficient method for advanced HCC patients with hypersplenism treated by chemotherapy.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2008.00389.x","type":"journal-article","created":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T05:23:39Z","timestamp":1215581019000},"page":"1172-1177","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of splenectomy for hypersplenic patients with advanced hepatocellular 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