{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:16:31Z","timestamp":1697001391004},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,8,18]],"date-time":"2008-08-18T00:00:00Z","timestamp":1219017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> Several surgical procedures have been developed for reducing portal vein pressure to prevent postoperative liver injury. Nitric oxide synthase expression (NOS) induced by elevation of portal vein pressure is thought to play an important role in liver regeneration, but the details are not well understood.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Rats in the control group and in the subcutaneous splenic transposition (SST) group underwent 90% partial hepatectomy. Survival and portal vein pressure were analyzed. The serum IL\u20106 and TNF\u2010\u03b1 levels were measured by enzyme\u2010linked immunosorbent assay (ELISA). Hepatocyte proliferation and apoptosis 12 hours after hepatectomy were analyzed immunohistochemically. The protein and messenger RNA expression of inducible and endothelial NOS were analyzed using Western blotting and quantitative reverse transcriptase polymerase chain reaction, respectively.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The survival rate of the SST group was significantly higher. Portal vein pressure, TNF\u2010\u03b1 level and the apoptotic index were significantly lower in the SST group. Twelve hours after surgery, liver inducible NOS (iNOS) protein expression was significantly lower in the SST group. However, protein expression of endothelial NOS was not significantly different between the groups.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Inducible NOS expression after extended hepatectomy is related to the effects of porto\u2010systemic shunting on the splanchnic circulation. Also, iNOS induction and concomitant nitric oxide generation appear to participate in the cytotoxicity of excessive portal pressure after extended hepatectomy.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2008.00404.x","type":"journal-article","created":{"date-parts":[[2008,8,18]],"date-time":"2008-08-18T14:50:43Z","timestamp":1219071043000},"page":"78-85","source":"Crossref","is-referenced-by-count":3,"title":["Effect of porto\u2010systemic shunting on NOS expression after extended hepatectomy in 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