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Hence nutritional management in patients with chronic liver disease must receive high priority. The use of BCAA supplementation has been a controversial subject. This review summarizes published results of BCAA supplementation as a nutritional therapy for patients with cirrhosis and hepatocellular carcinoma (HCC). On balance, it would be appropriate to conclude that BCAA are associated with decreased frequency of complications of cirrhosis and improved nutritional status when prescribed as a maintenance therapy for patients with cirrhosis. More studies are, however, required to identify those who might benefit most from BCAA supplementation.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2008.00435.x","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T06:12:11Z","timestamp":1229321531000},"source":"Crossref","is-referenced-by-count":22,"title":["Role of branched\u2010chain amino acids in management of cirrhosis and hepatocellular carcinoma"],"prefix":"10.1111","volume":"38","author":[{"given":"Vincent W.","family":"Lam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronnie T.","family":"Poon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,15]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"392","volume-title":"Clinical Nutrition\u2010Parenteral Nutrition","author":"Fan ST","year":"2001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2006.02.001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.295S"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/63.4.602"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00210228"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.6.1194"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0443"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.01.018"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(02)00984-X"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230516"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412083312303"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(01)00521-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.314S"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.6.1596S"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.07.022"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.07.016"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92119-6"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018831302578"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF03029165","article-title":"Effects of total parenteral nutrition enriched with branched chain amino acid infusion on liver function and serum amino acid pattern in dogs undergoing hepatectomy","volume":"15","author":"De Caterina M","year":"1985","journal-title":"Ric Clin Lab"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/014860718601000117"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02339-2"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/315742"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2004.04.005"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420090109016"},{"key":"e_1_2_6_26_2","unstructured":"FerenciP FunovicsJ WewalkaF.Therapy of hepatic encephalopathy. 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