{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T21:55:06Z","timestamp":1765230906328},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T00:00:00Z","timestamp":1227830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Hepatopoietin Cn (HPPCn) is a member of the leucine\u2010rich acidic nuclear protein family (LANP), and studies of partially hepatectomized (PH) mice show that levels of HPPCn mRNA increase following liver injury. Furthermore, the recombinant human protein (rhHPPCn) was shown to stimulate hepatic DNA synthesis and activate signaling pathways involved in hepatocyte proliferation <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Aim:\u2002<\/jats:bold> The aim of the study was to evaluate the protective effect of rhHPPCn on liver injury and fibrosis induced by carbon tetrachloride (CCl4) injection.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Wistar rats weighing 200\u2003g were given a single and repeated intraperitoneal injections of CCl4. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity in rat serum were measured using biochemical assay. Hepatic hydroxyproline (Hyp) level was determined in the hydrolysates of liver samples. Immunostaining and Masson's trichrome staining were conducted to evaluate hepatocyte proliferation and fibrosis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The results showed that exogenous rhHPPCn could alleviate hepatocyte necrosis and protect the liver from the development of fibrotic lesions by proliferation stimulation. Additionally, HPPCn could reduce ALT\/AST levels in rat serum following single and repeated CCl4 injection.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> It was suggested that HPPCn could protect hepatocytes from injury induced by CCl4 as a proliferation stimulator.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2008.00447.x","type":"journal-article","created":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T06:12:32Z","timestamp":1227852752000},"page":"200-206","source":"Crossref","is-referenced-by-count":15,"title":["The protective role of Hepatopoietin Cn on liver injury induced by carbon tetrachloride in rats*"],"prefix":"10.1111","volume":"39","author":[{"given":"Chun\u2010Ping","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da\u2010Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu\u2010Tse","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,21]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_2_4_3_2","first-page":"857","article-title":"Relationship between the proliferative capability of hepatocytes and the intrahepatic expression of hepatocyte growth factor and c\u2010Met in the course of cirrhosis development in rats","volume":"17","author":"Inoue H","year":"2006","journal-title":"Int J Mol Med"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.22747"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00309-X"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22126"},{"key":"e_1_2_4_7_2","first-page":"503","article-title":"Repeated intravenous injection of recombinant human hepatocyte growth factor ameliorates liver cirrhosis but causes albuminuria in rats","volume":"17","author":"Kusumoto K","year":"2006","journal-title":"Int J Mol Med"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000031827.16102.C1"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.04867.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.08.023"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1539\/joh.49.249"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64835-3"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(85)80790-0"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(89)90050-8"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1993.1069"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(02)00341-4"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1103"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000253900.66640.34"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21285"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1872-034X.2008.00447.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1872-034X.2008.00447.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T20:57:27Z","timestamp":1697317047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1872-034X.2008.00447.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,21]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1111\/j.1872-034X.2008.00447.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1872-034x.2008.00447.x","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,21]]}}}