{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:34:52Z","timestamp":1761561292531},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,11,13]],"date-time":"2008-11-13T00:00:00Z","timestamp":1226534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> A large cohort study in Japan revealed that the specific viral profile may influence the fulminant outcome in acute hepatitis B virus (HBV) infections, while the genetic influence on outcome has not been clarified in patients with acute exacerbation of chronic liver disease caused by HBV. We experienced a case of fatal liver failure that developed as the result of chronic HBV infection. To determine possible genetic factor involving acute exacerbation, genetic analysis of serum from the patient and his siblings was performed.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> HBV subgenotype as well as pre\u2010core\/core\u2010promoter mutations of samples mentioned above were determined.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Patient had HBV\u2010Bj with pre\u2010core (1896\/1899) and core\u2010promoter (1762\/1764) mutations, the genomic profile frequently seen in fulminant hepatitis caused by acute HBV infection.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This result suggests that determination of the HBV subgenotype and pre\u2010core\/core promoter mutations could provide a rationale for development of a treatment strategy in asymptomatic HBV carriers.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2008.00460.x","type":"journal-article","created":{"date-parts":[[2008,11,13]],"date-time":"2008-11-13T08:03:24Z","timestamp":1226563404000},"page":"341-345","source":"Crossref","is-referenced-by-count":5,"title":["Impact of determination of hepatitis B virus subgenotype and pre\u2010core\/core\u2010promoter mutation for the prediction of acute exacerbation of asymptomatic carriers"],"prefix":"10.1111","volume":"39","author":[{"given":"Tadashi","family":"Ikegami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Matsuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Mizokami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21249"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1996.tb00657.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005350170103"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.9.2899-2903.1999"},{"key":"e_1_2_5_6_2","first-page":"406","article-title":"The neighbor\u2010joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou N","year":"1987","journal-title":"Mol Biol Evol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50140"},{"key":"e_1_2_5_8_2","first-page":"216","article-title":"Two subtypes (subgenotypes) of hepatitis B virus genotype C: a novel subtyping assay based on restriction fragment length polymorphism","volume":"33","author":"Tanaka Y","year":"2005","journal-title":"Hepatol Res"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-006-5099-3"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20824"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000090789"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21345"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.11.1630"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1872-034X.2008.00460.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1872-034X.2008.00460.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:38:35Z","timestamp":1696966715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1872-034X.2008.00460.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,26]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1111\/j.1872-034X.2008.00460.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1872-034x.2008.00460.x","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,26]]}}}