{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T05:06:07Z","timestamp":1722661567383},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,4,7]],"date-time":"2009-04-07T00:00:00Z","timestamp":1239062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> A nationwide survey in Japan revealed that nearly one\u2010fifth of human immunodeficiency virus (HIV)\u2010positive patients are co\u2010infected with hepatitis C virus (HCV). We conducted a study to further analyze the features of liver disease in HIV\u2013HCV co\u2010infected patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We analyzed 297 patients from eight hospitals belonging to the HIV\/AIDS Network of Japan.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> HCV genotypes 1, 2, 3, 4 and mixed genotypes were detected in 55.2, 13.7, 18.9, 0.9 and 11.3% of patients, respectively, in contrast to the fact that only genotypes 1 and 2 are detected in HCV mono\u2010infected patients in Japan. This is compatible with the transmission of HCV through imported blood products contaminated by HCV. Sixteen of 297 HIV\u2013HCV co\u2010infected patients had advanced liver disease accompanied by ascites, hepatic encephalopathy or hepatocellular carcinoma. The average age of such patients was 41.1 \u00b1 14.0 years, which was much younger than that of HCV mono\u2010infected patients with the same complications. The progression speed of liver disease estimated from the changes in the levels of serum albumin, bilirubin, or platelet was slower in patients who achieved sustained virological response with interferon treatment than in those who did not receive it. The overall sustained virological response rate to interferon treatment was 43.3%.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our findings suggest that liver disease is more advanced in HIV\u2013HCV co\u2010infected patients than in HCV mono\u2010infected patients, and interferon treatment may retard the progression of liver disease in such patients.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2009.00517.x","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T01:53:20Z","timestamp":1239155600000},"page":"657-663","source":"Crossref","is-referenced-by-count":15,"title":["Chronic hepatitis C in patients co\u2010infected with human immunodeficiency virus in Japan: a retrospective multicenter 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