{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:00:26Z","timestamp":1761919226156},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,4,23]],"date-time":"2009-04-23T00:00:00Z","timestamp":1240444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Host and viral factors can promote the development of fulminant hepatitis B (FHB), but there have been no case\u2013control studies for figuring out virological parameters that can distinguish FHB.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> In a case\u2013control study, virological factors associated with the development of FHB were sought in 50 patients with FH developed by transient hepatitis B virus (HBV) infection (FH\u2010T) and 50 with acute self\u2010limited hepatitis B (AHB) who were matched for sex and age. In addition, 12 patients with FH developed by acute exacerbation (AE) of asymptomatic HBV carrier (ASC) (FH\u2010C) were also compared with 12 patients without FH by AE of chronic hepatitis B (AE\u2010C).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Higher HBV DNA levels, subgenotype B1\/Bj, A1762T\/G1764A, G1896A, G1899A and A2339G mutation were significantly more frequent (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), while hepatitis B e\u2010antigen was less frequent in the FH\u2010T patients than AHB. In multivariate analysis, G1896A mutation (odds ratio [OR], 13.53; 95% confidence interval [CI], 2.75\u201366.64), serum HBV DNA more than 5.23\u2003log copies\/mL (OR, 5.14; 95% CI, 1.10\u201324.15) and total bilirubin more than 10.35\u2003mg\/mL (OR, 7.81; 95% CI, 1.77\u201334.51) were independently associated with a fulminant outcome by transient HBV infection. On the other hand, in comparison with the patients between FH\u2010C and AE\u2010C groups, there was no significant difference of virological factors associated with the development of FHB.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> A number of virological factors have been defined that may distinguish FH\u2010T from AHB in a case\u2013control study. The pathogenic mechanism of FHB between transient HBV infection and AE of ASC would be different.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2009.00519.x","type":"journal-article","created":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T02:18:49Z","timestamp":1240539529000},"page":"648-656","source":"Crossref","is-referenced-by-count":35,"title":["Case\u2013control study for the identification of virological factors associated with fulminant hepatitis B"],"prefix":"10.1111","volume":"39","author":[{"given":"Atsunori","family":"Kusakabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Mochida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Sata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Isoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Hon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasukiyo","family":"Sumino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yatsuhashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Takikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gotaro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyasu","family":"Karino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Sakaida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namiki","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuminaka","family":"Sugauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Nojiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Joh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzo","family":"Miyakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Mizokami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,6,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2008.00322.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-5-1201"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-10-2575"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-1-67"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-83-8-2059"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000074988"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.33161"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20365"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.12.5985-5992.2002"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19633-0"},{"key":"e_1_2_6_12_2","first-page":"216","article-title":"Two subtypes (subgenotypes) of hepatitis B virus genotype C: a novel subtyping assay based on restriction fragment length polymorphism","volume":"33","author":"Tanaka Y","year":"2005","journal-title":"Hepatol Res"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/516458"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-4-199502150-00001"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242404"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21249"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242405"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.11.1630"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.04.004"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90964-E"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117006"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80019-4"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220603"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196810102791504"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770100346"},{"key":"e_1_2_6_26_2","unstructured":"FujiwaraK MochidaS MatsuiA.Prospective study for the efficiency of lamivudine for the patients with acute exacerbation of HBV carrier.Annual Report of Intractable Liver Disease Study Group of Japan the Ministry of Health Welfare and Labor2004. (In Japanese.)"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.2.439-445.2002"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.5.1901-1906.2003"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.9.2899-2903.1999"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-4-883"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00262.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.000333"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90713-7"},{"key":"e_1_2_6_34_2","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1128\/jvi.70.9.5845-5851.1996","article-title":"Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on pre\u2010core gene expression and viral replication","volume":"70","author":"Buckwold VE","year":"1996","journal-title":"J Virol"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.12.8102-8110.1994"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.7.3756-3762.1993"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406282101"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.5.3016-3027.2005"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.5.2247-2254.2004"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1997-5"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(86)80052-6"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1872-034X.2009.00519.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1872-034X.2009.00519.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T19:53:53Z","timestamp":1697399633000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1872-034X.2009.00519.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,22]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1111\/j.1872-034X.2009.00519.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1872-034x.2009.00519.x","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,22]]}}}