{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:15:31Z","timestamp":1779286531489,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T00:00:00Z","timestamp":1254268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>Portal hypertension is not a rare complication of PBC, but there are no useful clinical predictors of its severity. In fact, in PBC patients, the evaluation of portal hypertension needs a direct access to the portal vein in order to measure the real porto\u2010hepatic gradient (PHG), mainly because of a possible pre\u2010sinusoidal component. The severity of portal hypertension, as measured by the PHG using a thin needle, correlated significantly with the long\u2010term survival of PBC patients, but the initial Mayo score remained the best predictor of survival. In addition to the well\u2010known effects on biological parameters, ursodeoxycholic acid (UDCA) treatment has been associated with a stabilization or improvement of portal hypertension but this effect was not observed in all patients: \u201cresponders\u201d and \u201cnon\u2010responders\u201d to the UDCA could be identified according to changes in PHG and aspartate aminotransferase (AST) levels observed 2\u2003years after UDCA therapy and had significantly different long\u2010term survivals. This notion of \u201cresponders\u201d and \u201cnon\u2010responders\u201d is new and may well explain the conflicting data found in the literature concerning the effects of UDCA in PBC patients as reported in various clinical trials. These findings are of interest when considering the emerging non\u2010invasive methods aimed at evaluating liver fibrosis, particularly elastography that may prove useful in the indirect assessment of portal hypertension in the near future, therefore avoiding the need for the invasive measurement of the PHG.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2009.00550.x","type":"journal-article","created":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T06:53:09Z","timestamp":1254293589000},"page":"1032-1038","source":"Crossref","is-referenced-by-count":6,"title":["Portal hypertension in primary biliary cirrhosis (PBC): A reversible condition? 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