{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:46:04Z","timestamp":1788893164747,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T00:00:00Z","timestamp":1269907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p><jats:bold>Aims:\u2002<\/jats:bold> Anti\u2010gp210 and anti\u2010centromere antibodies are different risk factors for the progression of primary biliary cirrhosis (PBC). However, the association of human leukocyte antigen (HLA) polymorphisms with these risk factors is unknown.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We determined the <jats:italic>HLA\u2010DRB1<\/jats:italic> genotype in 334 Japanese PBC patients and studied their serum antibodies to gp210 and centromere during the 1\u2013452\u2010month observation period.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Anti\u2010gp210 (odds ratio [OR] 46.56, 95% confidence interval [CI], 9.20\u2013850.1) and anti\u2010centromere antibodies (OR, 2.36, 95% CI, 1.28\u20134.35) were significant risk factors for jaundice\u2010 and nonjaundice\u2010type progression, respectively. <jats:italic>HLA\u2010DRB1<\/jats:italic>*<jats:italic>0405<\/jats:italic> and *<jats:italic>0803<\/jats:italic> predisposed patients to anti\u2010gp210 (OR, 1.61, 95% CI, 1.08\u20132.39) and anti\u2010centromere (OR, 2.30, 95% CI, 1.41\u20133.73) antibody production, respectively. <jats:italic>HLA\u2010DRB1<\/jats:italic>*<jats:italic>1502<\/jats:italic> and *<jats:italic>0901<\/jats:italic> patients were predisposed to nonjaundice\u2010type progression (OR, 1.98, 95% CI, 1.13\u20133.40 and OR, 1.78, 95% CI, 1.02\u20133.03), while <jats:italic>HLA\u2010DRB1<\/jats:italic>*<jats:italic>0803<\/jats:italic> and *<jats:italic>0405<\/jats:italic> patients were predisposed to disease development (OR, 2.24, 95% CI, 1.48\u20133.41 and OR, 1.53, 95% CI, 1.11\u20132.11, respectively). Stratifying patients by <jats:italic>HLA\u2010DRB1<\/jats:italic> alleles revealed that anti\u2010gp210 antibodies was a strong risk factor, regardless of the <jats:italic>HLA\u2010DRB1<\/jats:italic> alleles for jaundice\u2010type progression, while anti\u2010centromere antibodies was a significant risk factor for nonjaundice\u2010type progression in patients with <jats:italic>HLA\u2010DRB1<\/jats:italic>*<jats:italic>0405<\/jats:italic> (OR, 6.89, 95% CI, 2.18\u201326.56) and \u2010DRB1*0803 (OR, 5.42, 95% CI, 1.47\u201324.62) but not other <jats:italic>HLA\u2010DRB1<\/jats:italic> alleles.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>  <jats:italic>HLA\u2010DRB1<\/jats:italic> polymorphisms are significantly associated with not only disease development and progression but also antinuclear antibody production and the determination of the relative risk of antinuclear antibodies that contribute to PBC disease progression.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2010.00631.x","type":"journal-article","created":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T03:25:27Z","timestamp":1270005927000},"page":"494-504","source":"Crossref","is-referenced-by-count":48,"title":["Analysis of <i>HLA\u2010DRB1<\/i> polymorphisms in Japanese patients with primary biliary cirrhosis (PBC): The HLA\u2010DRB1polymorphism determines the relative risk of antinuclear antibodies for disease progression in 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