{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:22:25Z","timestamp":1761675745882},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T00:00:00Z","timestamp":1271203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> The present study was undertaken to evaluate the effects of 1\u2010O\u2010hexyl\u20102,3,5\u2010trimethylhydroquinone (HTHQ), a synthesized vitamin E derivative, on carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced cirrhosis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Rats were treated with hypodermic injections of CCl<jats:sub>4<\/jats:sub> twice a week to induce the hepatic cirrhosis, and given drinking water containing HTHQ or solvent. Primary cultures of rat hepatocytes were performed to evaluate the effects of HTHQ on the expression of inducible nitric oxide synthase (iNOS).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Masson's staining of rat livers showed fibrosis around pseudo\u2010lobules in the CCl<jats:sub>4<\/jats:sub> group, the lesions being reduced in the CCl<jats:sub>4<\/jats:sub> HTHQ group. Increases in liver tissue hydroxyproline and \u03b1<jats:sub>1<\/jats:sub>(I) collagen, \u03b1\u2010smooth muscle actin and iNOS induced by CCl<jats:sub>4<\/jats:sub>, were also markedly diminished by HTHQ. Furthermore, both HTHQ and vitamin E attenuated interleukin\u20101\u03b2\u2010induced iNOS protein expression in cultured hepatocytes, the potency of HTHQ being 10\u2010times higher than that of vitamin E.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> HTHQ may inhibit development of hepatic cirrhosis in rats, more potently than vitamin E, by inhibiting the iNOS expression in hepatocytes. Because vitamin E has a radical scavenging action, roles of NO and peroxynitrite will be discussed in the effects of HTHQ on the fibrosis.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2010.00638.x","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T14:22:47Z","timestamp":1271254967000},"page":"613-621","source":"Crossref","is-referenced-by-count":12,"title":["Effects of 1\u2010O\u2010hexyl\u20102,3,5\u2010trimethylhydroquinone on carbon tetrachloride\u2010induced hepatic cirrhosis in rats"],"prefix":"10.1111","volume":"40","author":[{"given":"Jun","family":"An","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010Gang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Nonami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuro","family":"Koide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Tsunekawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokutaro","family":"Miki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohisa","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,5,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-008-8091-0"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90564.2008"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840130226"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00197389"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00026-6"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80140-1"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.4049\/jimmunol.155.10.4890","article-title":"A central role for IL\u20101 beta in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. 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