{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:19:37Z","timestamp":1791908377548,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T00:00:00Z","timestamp":1285632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> Liver dysfunction is not rare in patients with collagen disease. We sought to elucidate the clinical features of liver dysfunction in the presence of collagen disease.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We analyzed the frequency and causes of liver dysfunction in 607 patients (rheumatoid arthritis [RA], <jats:italic>n<\/jats:italic>\u2003=\u2003220; systemic lupus erythematosus [SLE], <jats:italic>n<\/jats:italic>\u2003=\u2003164; systemic sclerosis [SSc], <jats:italic>n<\/jats:italic>\u2003=\u200347; Sj\u00f6gren's syndrome [SjS], <jats:italic>n<\/jats:italic>\u2003=\u200344; Beh\u00e7et's disease, <jats:italic>n<\/jats:italic>\u2003=\u200343; polymyositis\/dermatomyositis [PM\/DM], <jats:italic>n<\/jats:italic>\u2003=\u200327; vasculitis syndrome, <jats:italic>n<\/jats:italic>\u2003=\u200325; mixed connective tissue disease [MCTD], <jats:italic>n<\/jats:italic>\u2003=\u200321; and adult\u2010onset Still's disease [AOSD], <jats:italic>n<\/jats:italic>\u2003=\u200316).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Liver dysfunction was observed in 238 (39.2%) of 607 patients showing collagen disease. Patients with AOSD (81.3%), PM\/DM (51.9%) and vasculitis syndrome (48.0%) frequently displayed liver dysfunction. Liver dysfunction in collagen diseases results from many causes; drug\u2010induced liver injury (26.1%), fatty liver (7.6%), viral hepatitis (1.3%), autoimmune hepatitis (4.2%), primary biliary cirrhosis (15.9%) and the collagen disease itself (15.5%). Conversely, primary biliary cirrhosis was a leading cause in SSc (76.1%) and SjS (70.0%). Liver dysfunction in collagen disease tended to be mild. In addition, alanine aminotransferase levels correlated positively with ferritin levels in AOSD (<jats:italic>R<\/jats:italic>\u2003=\u20030.708, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Moreover, alkaline phosphatase levels correlated positively with C reactive protein levels in vasculitis syndrome (<jats:italic>R<\/jats:italic>\u2003=\u20030.833, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Liver dysfunction in the presence of collagen disease has various causes, and dysfunction associated with collagen disease reflects the activity of the collagen disease itself.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2010.00707.x","type":"journal-article","created":{"date-parts":[[2010,9,29]],"date-time":"2010-09-29T03:46:26Z","timestamp":1285731986000},"page":"1092-1097","source":"Crossref","is-referenced-by-count":65,"title":["Clinical features of liver dysfunction in collagen 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