{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:20:42Z","timestamp":1793996442256,"version":"4.8.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T00:00:00Z","timestamp":1288051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> Primary biliary cirrhosis (PBC) is a chronic cholestatic disease which is associated with hypercholesterolaemia. Further, cholestatic diseases are associated with deficiencies of anti\u2010oxidant vitamins. Despite these associations PBC is not associated with an increase in cardiovascular mortality. The aim of this study is to assess if primary biliary cirrhosis is associated with oxidative stress, endothelial dysfunction and alteration of vascular compliance which is a surrogate marker for cardiovascular risk.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Fifty\u2010one PBC patients and 34 control subjects were studied. Lipid soluble vitamins A, and E in addition to ascorbate and carotenoids were measured to assess anti\u2010oxidant status. C\u2010reactive protein, hydroperoxides and adhesion molecules sICAM\u2010l\/sVCAM\u2010l were assessed as serological measures of endothelial function. Finally, measures of vascular compliance were assessed by applanation tonometer.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> CRP, sICAM and sVCAM were all significantly higher in PBC patients (469.14 vs 207.13, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001; 768.12 vs 308.03,<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001; 708.40 vs 461.31, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) whilst anti\u2010oxidant vitamin levels were lower in PBC patients, with ascorbate, vitamin E and vitamin A all significantly lower in PBC patients (39.91 vs 72.68, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001; 2.63 vs 3.14, <jats:italic>P<\/jats:italic>\u2003=\u20030.02; 1.08 vs 1.81, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Despite these findings PBC patients have a lower pulse wave velocity than control subjects (8.22\u2003m\/s vs 8.78\u2003m\/s, <jats:italic>P<\/jats:italic>\u2003=\u20030.022).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> PBC patients appear to have reduced vascular risk as assessed by pulse wave velocity but concurrently have evidence of endothelial dysfunction, inflammation and anti\u2010oxidant deficiency.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2010.00717.x","type":"journal-article","created":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T02:58:42Z","timestamp":1288148322000},"page":"1098-1106","source":"Crossref","is-referenced-by-count":29,"title":["Primary biliary cirrhosis is associated with oxidative stress and endothelial dysfunction but not increased cardiovascular risk"],"prefix":"10.1111","volume":"40","author":[{"given":"William J.","family":"Cash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"McCance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"McEneny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.","family":"Cadden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil I.","family":"McDougall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Callender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(05)80080-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709025067"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150518"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.2.265"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb05837.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80292-3"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000178953"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.5.710"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(99)00118-X"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80016-X"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260118"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03300.x"},{"key":"e_1_2_5_14_2","first-page":"476","article-title":"Elevated level of serum Mn\u2010superoxide dismutase in patients with primary biliary cirrhosis: possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis","volume":"118","author":"Ono M","year":"1991","journal-title":"J Lab Clin Med"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(02)00225-9"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840090403"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.04134.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840010412"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/hq0102.101770"},{"key":"e_1_2_5_20_2","first-page":"S147","article-title":"Pulse wave analysis","volume":"14","author":"O'Rourke MF","year":"1996","journal-title":"J Hypertens Suppl"},{"key":"e_1_2_5_21_2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1042\/cs1030379","article-title":"Arterial stiffness and pulse contour analysis: an age old concept revisited","volume":"103","author":"Cockcroft JR","year":"2002","journal-title":"Clin Sci (Lond)"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)80019-Q"},{"key":"e_1_2_5_23_2","first-page":"126","article-title":"Clinical chemical methods for the routine assessment of the vitamin status in human populations. 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