{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:57:30Z","timestamp":1773277050600,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,26]],"date-time":"2011-01-26T00:00:00Z","timestamp":1296000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> Recently, the associations of +49A\/G polymorphisms of cytotoxic T\u2010lymphocyte antigen 4 (CTLA\u20104) gene with the susceptibility to type 1 autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) have been reported; however these associations are yet to be fully elucidated. This study aimed to identify the associations of CTLA\u20104 gene +49A\/G polymorphisms with the susceptibility to type 1 AIH and PBC by using a meta\u2010analysis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> PubMed was searched by using the following keywords: \u201c<jats:italic>autoimmune hepatitis<\/jats:italic> AND (<jats:italic>polymorphism<\/jats:italic> OR<jats:italic> polymorphisms<\/jats:italic>)\u201d or \u201c<jats:italic>primary biliary cirrhosis<\/jats:italic> AND (<jats:italic>polymorphism<\/jats:italic> OR<jats:italic> polymorphisms<\/jats:italic>)\u201d. Meta\u2010analyses of five studies including 526 patients with type 1 AIH and 631 controls and seven studies including 1500 patients with PBC and 2345 controls were performed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> For type 1 AIH, the odds ratio (OR) of G allele was 1.26 [95% confidence interval (CI) 1.06\u20131.51] although G\/G homozygosity was not associated with the susceptibility to type 1 AIH. On the other hand, the OR of A\/A homozygosity for type 1 AIH was 0.66 (95% CI 0.50\u20130.86). For PBC, the OR of G allele was 1.20 (95% CI 1.06\u20131.34). Furthermore, G\/G homozygosity was significantly associated with the susceptibility to PBC (OR 1.29, 95% CI 1.01\u20131.66). The OR of A\/A homozygosity for PBC was 0.81 (95% CI 0.70\u20130.94).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> This study suggests that CTLA\u20104 gene +49A\/G polymorphisms may be associated with the susceptibility to type 1 AIH and PBC. Especially, while G\/G genotype may be associated with the susceptibility to PBC, A\/A genotype may be protective against type 1 AIH and PBC.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2010.00757.x","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T02:21:08Z","timestamp":1296094868000},"page":"151-159","source":"Crossref","is-referenced-by-count":17,"title":["+49A\/G polymorphism of cytotoxic T\u2010lymphocyte antigen 4 gene in type 1 autoimmune hepatitis and primary biliary cirrhosis: A 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