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Statins, 3\u2010hydroxy\u20103\u2010methyglutaryl\u2010coenzyme A reductase inhibitors, are well known to reduce low\u2010density lipoprotein cholesterol and reduce the incidence of coronary heart disease and other major vascular events by anti\u2010inflammatory and antifibrotic effects, and antiproliferative properties in colorectal cancers have also been reported. Recently, statins have been reported to improve hepatic steatosis; however, the effect on fibrosis is controversial.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The effects of pitavastatin (one of the strongest statins) were examined using a choline\u2010deficient L\u2010amino acid\u2010defined (CDAA) diet liver fibrosis model.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Pitavastatin significantly attenuated increases in serum aspartate aminotransferase, alanine aminotransferase, hepatic steatosis, oxidative stress, pre\u2010neoplastic lesions (glutathione S\u2010transferase placental form\u2010positive lesions), expression of cytokines, such as tumor necrosis factor\u2010\u03b1 and transforming growth factor\u2010\u03b21, and the expression of tissue inhibitor of metalloproteinase\u20101, tissue inhibitor of metalloproteinase\u20102 and type I procollagen genes followed by attenuating fibrosis of the liver of CDAA\u2010fed rats.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These results indicate that pitavastatin may inhibit steatosis, hepatic fibrosis and carcinogenesis in rat model of NASH.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2010.00769.x","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T09:04:10Z","timestamp":1296464650000},"page":"375-385","source":"Crossref","is-referenced-by-count":30,"title":["Pitavastatin inhibits hepatic steatosis and fibrosis in non\u2010alcoholic steatohepatitis model 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