{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:58:42Z","timestamp":1772722722890,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T00:00:00Z","timestamp":1298505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> Autoimmune hepatitis (AIH) is a chronic hepatitis of unknown etiology, although several cytokines have been implicated in its pathogenesis and severity. This study investigated the relationship between circulating cytokines in the pretreatment phase and remission following corticosteroid therapy phase in Japanese AIH patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 28 cytokines were measured simultaneously by multiple bead array technology in the sera of 40 patients with AIH collected during pretreatment and remission phases.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Interleukin (IL)\u201012p40, interferon\u2010\u03b3\u2010inducible protein (IP\u201010), macrophage inflammatory protein (MIP)\u20101\u03b1, MIP\u20101\u03b2, IL\u201017F and IL\u201018 were significantly decreased during remission from pretreatment stage levels. The level of IP\u201010 in the pretreatment phase was correlated with serum levels of alanine aminotransferase.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Our results suggest that a complex interplay of several cytokines, especially pro\u2010inflammatory and T\u2010helper 17 cytokines and regulatory T\u2010cell suppression by IL\u201012p40 may play a pivotal role in the pathogenesis of AIH.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2011.00773.x","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T15:32:21Z","timestamp":1298734341000},"page":"350-357","source":"Crossref","is-referenced-by-count":19,"title":["Cytokine profiles affecting the pathogenesis of autoimmune hepatitis in Japanese patients"],"prefix":"10.1111","volume":"41","author":[{"given":"Atsushi","family":"Kamijo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaname","family":"Yoshizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Joshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suguru","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeji","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Ichijo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050408"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5980"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90041-V"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.12.019"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21518"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2008.00337.x"},{"key":"e_1_2_6_9_2","first-page":"5","article-title":"Two types of murine helper T cell clone. 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