{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T13:33:56Z","timestamp":1700573636206},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T00:00:00Z","timestamp":1316995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> Hepatic steatosis is one of the factors limiting the virological response to interferon\u2010based antiviral therapy for chronic hepatitis C (CH\u2010C) patients infected with genotype 1, while contradictory results have been reported for genotype 2. We aimed to clarify the effect of hepatic steatosis on therapeutic outcome and cumulative positivity of serum HCV RNA in CH\u2010C patients infected with genotype 2 treated by peginterferon (PEG\u2010IFN)\u03b12b and ribavirin (RBV) combination therapy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 74 treatment\u2010na\u00efve non\u2010cirrhotic CH\u2010C patients infected with genotype 2 who received PEG\u2010IFN\u03b12b and RBV according to the standard regimen were divided into hepatic steatosis 0\u201310% and &gt;10% groups. The clinical backgrounds, sustained virological response (SVR) rates and cumulative positivity of serum HCV RNA were compared between the two groups.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Among the 74 patients, 61 (82.4%) had hepatic steatosis 0\u201310% and 13 (17.6%) had hepatic steatosis &gt;10%. Scores of homeostasis model assessment\u2010insulin resistance and hepatic fibrosis were higher in patients with hepatic steatosis &gt;10% than hepatic steatosis 0\u201310% (<jats:italic>P<\/jats:italic>\u2003=\u20030.040 and 0.042, respectively). Non\u2010SVR was more frequent in patients with hepatic steatosis &gt;10% than hepatic steatosis 0\u201310% (<jats:italic>P<\/jats:italic>\u2003=\u20030.003). Cumulative positivity of serum HCV RNA was significantly higher in patients with hepatic steatosis &gt;10% than hepatic steatosis 0\u201310% (<jats:italic>P<\/jats:italic>\u2003=\u20030.004).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In CH\u2010C patients infected with genotype 2 treated by PEG\u2010IFN\u03b12b and RBV combination therapy, hepatic steatosis &gt;10% was associated with increased insulin resistance, advanced hepatic fibrosis and higher cumulative positivity of serum HCV RNA, which lead to a higher risk of non\u2010SVR.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2011.00886.x","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T00:28:34Z","timestamp":1317169714000},"page":"1145-1152","source":"Crossref","is-referenced-by-count":8,"title":["Hepatic steatosis in chronic hepatitis C patients infected with genotype 2 is associated with insulin resistance, hepatic fibrosis and affects cumulative positivity of serum hepatitis C 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