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However, there is insufficient evidence that IFN therapy inhibits hepatic carcinogenesis in patients with chronic hepatitis B. There are few cases of HCC due to chronic hepatitis B, and long\u2010term follow\u2010up periods verifying the inhibitory effect of IFN on hepatic carcinogenesis have not been obtained. To improve the prognosis of type B chronic liver diseases, it is important that hepatitis treatment follows guidelines in which a patient's age and the extent of hepatic fibrosis are taken into account. As for chronic hepatitis C, since a sustained virological response (SVR) in IFN therapy inhibits hepatic carcinogenesis and improves prognosis, treatment that aims for an SVR while taking into consideration host\u2010sided and virus\u2010sided factors is recommended for patients with type C chronic liver diseases. In areas with low incidence of HCC (e.g. USA), a large number of cases and a long\u2010term follow\u2010up period are needed before it can be accepted that IFN therapy inhibits hepatic carcinogenesis. After locally curative treatment of HCC, IFN therapy suppresses recurrence and improves survival rates.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2011.00889.x","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T00:30:10Z","timestamp":1317169810000},"page":"22-32","source":"Crossref","is-referenced-by-count":7,"title":["Anticarcinogenic impact of interferon therapy on the progression of hepatocellular carcinoma in patients with chronic viral 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