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For diagnosis of AIH using the new simplified criteria proposed by the International Autoimmune Hepatitis Group, it is necessary to re\u2010evaluate the antibody titer determined by using HEp\u20102 cells, which are widely used in Japan, and the finding of emperipolesis in liver histology, although the criteria are useful for rapid identification of AIH in routine clinical practice. The use of azathioprine as first\u2010line therapy for AIH is limited in Japan because the drug is not covered by the Japanese national health insurance. Concomitant use of ursodeoxycholic acid (UDCA) to reduce corticosteroids and use of UDCA as monotherapy are therefore considered promising. Moreover, a relatively good survival rate has been reported in patients who developed AIH\u2010induced acute liver failure and underwent living\u2010donor liver transplantation. Current trends in the diagnosis and treatment of AIH in Japan are described in this report with a review of recent findings.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2011.00904.x","type":"journal-article","created":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T10:32:17Z","timestamp":1320229937000},"page":"131-138","source":"Crossref","is-referenced-by-count":12,"title":["Current trends in the diagnosis and treatment of autoimmune hepatitis in 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