{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:13:12Z","timestamp":1791303192288,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T00:00:00Z","timestamp":1326844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> Non\u2010alcoholic steatohepatitis (NASH) is a progressive form of non\u2010alcoholic fatty liver disease (NAFLD). Therefore, it is important to evaluate disease activity and distinguish NASH from simple steatosis in NAFLD. Technetium\u201099\u2003m\u20102\u2010methoxy\u2010isobutyl\u2010isonitrile (<jats:sup>99m<\/jats:sup>Tc\u2010MIBI) is a lipophilic cation designed for myocardial perfusion scintigraphy in the diagnosis of ischemic heart diseases, and its retention reflects mitochondrial function. It was reported that hepatic mitochondrial abnormalities would be an important predictive factor for NASH disease progression. The aim of this study was to examine the clinical usefulness of <jats:sup>99m<\/jats:sup>Tc\u2010MIBI liver scintigraphy for evaluating disease activity of NAFLD and distinguishing NASH from simple steatosis in patients with NAFLD.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Twenty\u2010six patients with biopsy\u2010proven NAFLD were enrolled. Clinicolaboratory tests and <jats:sup>99m<\/jats:sup>Tc\u2010MIBI liver scintigraphy were performed. To evaluate hepatic uptake, regions of interest were set at the liver and heart, and the uptake ratio of the liver to heart (liver\/heart ratio) was calculated.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> All patients with NAFLD were classified into three groups according to the NAFLD activity score: non\u2010NASH (simple steatosis) (<jats:italic>n<\/jats:italic>\u2003=\u20034), borderline NASH (<jats:italic>n<\/jats:italic>\u2003=\u200311), and NASH (<jats:italic>n<\/jats:italic>\u2003=\u200311). Liver\/heart ratios were significantly lower in NASH than in simple steatosis (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Moreover, liver\/heart ratios were significantly correlated with NAFLD activity scores among the patients (r\u2003=\u2003\u22120.413, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The present study indicates that <jats:sup>99m<\/jats:sup>Tc\u2010MIBI liver scintigraphy would be a useful non\u2010invasive functional imaging method with which to evaluate disease activity of NAFLD and distinguish NASH from simple steatosis.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2011.00923.x","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T12:25:14Z","timestamp":1326889514000},"page":"273-279","source":"Crossref","is-referenced-by-count":13,"title":["Usefulness of Technetium\u201099 m\u20102\u2010methoxy\u2010isobutyl\u2010isonitrile liver scintigraphy for evaluating disease activity of non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"42","author":[{"given":"Kosei","family":"Masuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsutaka","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Munekage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunehiro","family":"Ochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuto","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiji","family":"Saibara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011775"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1876-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22603"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20920"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000111245.75752.C6"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0912063"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i10.1579"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.12.3541"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0349"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23135"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0135"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.04.014"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.11.005"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23314"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192519"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0047-0740(84)90004-4"},{"key":"e_1_2_6_18_2","first-page":"1646","article-title":"Effect 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