{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T15:50:44Z","timestamp":1777132244093,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:00:00Z","timestamp":1339459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>We present a 43\u2010year\u2010old man with huge focal nodular hyperplasia (FNH) that was difficult to distinguish from well\u2010differentiated hepatocellular carcinoma (HCC). He previously had abnormal portal vein circulation due to hypoplasia of the intrahepatic portal vein, which was treated with a superior mesenteric vein\u2013inferior vena cava shunt. Laboratory findings included predominantly indirect hyperbilirubinemia with concomitant elevation in aspartate aminotransferase (AST), alanine aminotransferase (ALT), and ammonia. Serum \u03b1\u2010fetoprotein and des\u2010\u03b3\u2010carboxy prothrombin were slightly elevated. Multidetector\u2010row computed tomography detected the primary tumor in the left liver lobe, which partially showed a central stellate scar. Gd ethoxybenzyl diethylenetriamine pentaacetic acid\u2010enhanced magnetic resonance imaging showed some low\u2010intensity areas in the tumor in the hepatocyte phase. 99mTc\u2010galactosyl human serum albumin scintigraphy showed normal intake of agent in the tumor. We could not rule out well\u2010differentiated HCC. Extended left hepatectomy was performed. Final histopathological findings showed that most of the tumor was FNH against a background of portal vein hypoplasia with moderate atypia and hemorrhage. And immunohistochemical analysis revealed high expression of organic anion transporter (OATP) 1B3 and low expression of multidrug resistance\u2010associated protein (MRP) 2 in a part of the tumor. The patient has remained alive with no hepatic lesion for 1\u2003year after surgery. We describe a case of huge FNH that was difficult to distinguish from well\u2010differentiated HCC even by current fully preoperative imaging technology and demonstrate the effectiveness of curative surgical resection.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2012.00974.x","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T08:36:28Z","timestamp":1339490188000},"page":"727-731","source":"Crossref","is-referenced-by-count":8,"title":["Huge focal nodular hyperplasia difficult to distinguish from well\u2010differentiated hepatocellular carcinoma"],"prefix":"10.1111","volume":"42","author":[{"given":"Jun","family":"Hanaoka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Utsunomiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Imura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Morine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Ikemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,6,12]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199912000-00001"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.175.3.1750687"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840050622"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20615"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.11.043"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220341"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2007.06.011"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181705cd1"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.4.1"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03164939"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00092.x"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500030209"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841850600570474"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i40.6567"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/136518202760388046"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i11.1422"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00164.x"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1872-034X.2012.00974.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1872-034X.2012.00974.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T07:12:05Z","timestamp":1697353925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1872-034X.2012.00974.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,12]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1872-034X.2012.00974.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1872-034x.2012.00974.x","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,12]]}}}