{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:14:45Z","timestamp":1697444085086},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> Diabetes mellitus (DM) has been reported to worsen the long\u2010term prognosis of cirrhotic patients, and many studies have reported that DM is an independent risk factor for hepatocellular carcinoma. However, an accurate diagnosis of DM is sometimes difficult in cirrhotic patients. Recently, a novel non\u2010invasive <jats:sup>13<\/jats:sup>C\u2010glucose breath test has been reported to be useful for diagnosing insulin resistance in non\u2010cirrhotic patients. The aim of this study was to evaluate the efficacy of this tool for the identification of DM in cirrhotic patients.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thirty eight cirrhotic patients with normal fasting serum glucose and hemoglobin A1c levels underwent the <jats:sup>13<\/jats:sup>C\u2010glucose breath test and the oral glucose tolerance test. Blood and breath samples were collected at baseline and at 30, 60 and 120\u2003min after ingestion of 100\u2003mg <jats:sup>13<\/jats:sup>C\u2010labeled glucose and 75\u2003g glucose.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There was a strong correlation between the change in the concentrations at 2\u2003h for the measured <jats:sup>13<\/jats:sup>C\u2010glucose breath test (2h\u2010BT) and the 2\u2003h plasma glucose level (<jats:italic>r<\/jats:italic>\u2003=\u2003\u22120.60, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). In a receiver\u2013operator curve analysis using the 2h\u2010BT, the area under the curve was determined to be 0.88, with a sensitivity and specificity (cut\u2010off value of 3.5\u2030) of 82% and 85%, respectively, for the detection of DM. Multivariate analysis showed the 2h\u2010BT to be an independent parameter to identify DM.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The <jats:sup>13<\/jats:sup>C\u2010glucose breath test is a useful tool and has the potential to become a routine outpatient examination for the screening of DM in cirrhotic patients.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2012.01035.x","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T13:44:45Z","timestamp":1334670285000},"page":"1196-1201","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a novel non\u2010invasive <sup>13<\/sup>C\u2010glucose breath test for the identification of diabetes mellitus in cirrhotic 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