{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:19:57Z","timestamp":1792189197372,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,6,3]],"date-time":"2012-06-03T00:00:00Z","timestamp":1338681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> Some regions associated with sensitivity to interferon\u2010\u03b1 and ribavirin have been identified in the hepatitis C virus (HCV) genome, including amino acid 70 in the core region (core a.a. 70), a.a. 2209\u20132248 (interferon sensitivity\u2010determining region, ISDR) and a.a. 2334\u20132379 (interferon and ribavirin resistance\u2010determining region, IRRDR).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We examined changes in the sequences of these regions in 25 patients with chronic HCV genotype 1 infection who had not had sustained virological response (SVR) to interferon\u2010\u03b1 and ribavirin for 24\u201348\u2003weeks and subsequently received retreatment for 48\u201372\u2003weeks.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> At baseline, the core a.a. 70 was mutant (resistant) type in seven patients. At the start of retreatment, the core a.a. 70 had changed from sensitive to resistant type in 2 patients, and SVR was not achieved by retreatment. The ISDR variations were resistant type (0\u20131 mutations) in 17 patients at baseline. After 2\u2003weeks of treatment, amino acid change was found in two patients; in one, the substitutions returned to baseline status after treatment, and in the other, the substitution persisted. At the start of retreatment, ISDR sequences had changed from resistant to sensitive type in two patients and SVR was achieved and from sensitive to resistant type in three patients and SVR was not achieved. The IRRDR variations were resistant type (&lt;6 mutations) in 19 patients at baseline and at the start of retreatment.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Sequences of the core region and ISDR sometimes change during anti\u2010HCV therapy, potentially affecting the outcomes of retreatment.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2012.01046.x","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T15:58:34Z","timestamp":1336060714000},"page":"1157-1167","source":"Crossref","is-referenced-by-count":11,"title":["Changes in sequences of core region, interferon sensitivity\u2010determining region and interferon and ribavirin resistance\u2010determining region of hepatitis C virus genotype 1 during interferon\u2010alpha and ribavirin therapy, and efficacy of 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