{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:20:46Z","timestamp":1771341646524,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Hepatoblastoma, a malignant tumor which arises occasionally in older children but very rarely in adults, exhibits divergent differentiation with embryonal cells, fetal hepatocytes and immature elements. This report describes an embryonal type hepatoblastoma with neuroendocrine differentiation in a 16\u2010year\u2010old patient, which was diagnosed postoperatively. Clinical and radiologic work\u2010up failed to reveal a primary gastrointestinal malignancy and no primary lesions were detected in any other organ. This feature of hepatoblastoma is considered to be a multidirectional differentiation of the small epithelial or stem cells of the liver. At 2\u2010year follow up, the patient remains symptom\u2010free, with normal laboratory and diagnostic imaging studies, and no recurrent or metastatic disease identified.<\/jats:p>","DOI":"10.1111\/j.1872-034x.2012.01070.x","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T09:31:49Z","timestamp":1361871109000},"page":"320-326","source":"Crossref","is-referenced-by-count":6,"title":["Neuroendocrine differentiation in embryonal type hepatoblastoma"],"prefix":"10.1111","volume":"43","author":[{"given":"Georgios P.","family":"Fragulidis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Chondrogiannis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonios","family":"Vezakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikaterini","family":"Melemeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agatha","family":"Kondi\u2010Pafiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Primetis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Polydorou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionysios C.","family":"Voros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1995.tb00099.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01707.x"},{"key":"e_1_2_6_4_2","first-page":"13","article-title":"Hepatoblastoma in adult: review of the literature","volume":"1","author":"Zheng MH","year":"2009","journal-title":"J Clin Med Res"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2004.08.001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931115)72:10<2910::AID-CNCR2820721009>3.0.CO;2-4"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2001.42.4.431"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-006-0250-1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199009000-00006"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930715)72:2<361::AID-CNCR2820720209>3.0.CO;2-3"},{"issue":"5","key":"e_1_2_6_11_2","first-page":"442","article-title":"Primary mixed hepatocellular carcinoma with carcinoid characteristics. A case report","volume":"41","author":"Artopoulos JG","year":"1994","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711630111"},{"key":"e_1_2_6_13_2","first-page":"617","article-title":"\u201cNeuroendocrine\u201d differentiation in hepatocellular carcinomas (HCCs): immunohistochemical reactivity is related to distinct tumor cell types, but not to tumor grade","volume":"8","author":"Zhao M","year":"1993","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.1999.00866.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-010-0630-5"},{"issue":"2","key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.5858\/2005-129-234-MHIAA","article-title":"Mixed hepatoblastoma in an adult","volume":"129","author":"Kasper HU","year":"2005","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"e_1_2_6_17_2","first-page":"321","article-title":"Small epithelial cells and the histogenesis of hepatoblastoma. Electron microscopic, immunoelectron microscopic, and immunohistochemical findings","volume":"148","author":"Ruck P","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_6_18_2","first-page":"333","volume-title":"Pathology of Neoplasia in Children and Adolescents","author":"Weinberg AG","year":"1986"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10173"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10175"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80219-8"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.2750870.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000086486.52370.81"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20096"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.002"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4A6297.2004"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900301)65:5<1211::AID-CNCR2820650530>3.0.CO;2-M"},{"issue":"2","key":"e_1_2_6_28_2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/ajcp\/95.2.172","article-title":"Primary hepatic carcinoid tumor. An electron microscopic and immunohistochemical study","volume":"95","author":"Sioutos N","year":"1991","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005950300048"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2005.11.017"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-006-0251-0"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207782"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01611"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.47"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.07.012"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.10.022"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-419X(03)00005-2"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1162"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9072-2"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1385\/EP:11:3:243"},{"key":"e_1_2_6_41_2","first-page":"934","article-title":"Immunohistochemical evaluation of hepatoblastomas with use of the hepatocyte\u2010specific marker, hepatocyte paraffin 1, and the polyclonal anti\u2010carcinoembryonic antigen","volume":"11","author":"Fasano M","year":"1998","journal-title":"Mod Pathol"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1159\/000007635"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.44.958"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.72078"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.04.533"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-011-4497-z"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1177\/147323000803600428"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1872-034X.2012.01070.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1872-034X.2012.01070.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T21:20:31Z","timestamp":1697318431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1872-034X.2012.01070.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,26]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/j.1872-034X.2012.01070.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1872-034x.2012.01070.x","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,26]]}}}