{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:50:28Z","timestamp":1761630628207},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T00:00:00Z","timestamp":1350864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To clarify the role of disease recurrence as a cause of graft loss after living\u2010donor liver transplantation (<jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>) for primary biliary cirrhosis (<jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>), we investigated explant grafts, as well as the native liver and liver biopsy specimens, of patients who underwent retransplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 516 patients who underwent <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> and were registered in the Japanese <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>iver <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ransplant <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egistry, nine patients (1.7%) underwent retransplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven patients undergoing retransplantation later than 6 months after primary liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) were enrolled. All seven patients were female, with ages ranging from 34\u201357 years, and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>odel for <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nd\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tage <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>iver <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease scores ranging 10\u201328. The right lobe was used as graft in one and the left lobe in six. The initial immunosuppression regimen was tacrolimus in six and cyclosporin in one. The period between the primary <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> and retransplantation ranged 11\u2013120 months, with a median of 36 months. Three patients survived and four patients died due to poor graft functions or complications after retransplantation. The primary causes of primary graft loss revealed by histological examination of the explant livers were chronic rejection in three, portal thrombus and\/or steatohepatitis in three and outflow block in one. <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> recurrence was observed in 3 and the stage was mild in all.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> recurrence has a small impact as a cause of graft loss after <jats:styled-content style=\"fixed-case\">LDLT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1872-034x.2012.01108.x","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T12:17:20Z","timestamp":1348143440000},"page":"502-507","source":"Crossref","is-referenced-by-count":6,"title":["Disease recurrence plays a minor role as a cause for retransplantation after living\u2010donor liver transplantation for primary biliary cirrhosis: A multicenter study in <scp>J<\/scp>apan"],"prefix":"10.1111","volume":"43","author":[{"given":"Hiroto","family":"Egawa","sequence":"first","affiliation":[{"name":"Department of Surgery Institute of Gastroenterology Tokyo Women's Medical University  Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuni","family":"Nakanuma","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Graduate School of Medicine Kanazawa University  Kanazawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Maehara","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyushu University  Fukuoka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Uemoto","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  Kyoto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Nagasaki University  Nagasaki"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Niigata University  Niigata"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Shirabe","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyushu University  Fukuoka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhisa","family":"Takatsuki","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Nagasaki University  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