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Normal regulation of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:roman>AQP2<\/jats:roman>\n                    <\/jats:styled-content>\n                    by vasopressin involves 2 independent regulatory mechanisms: (1) short\u2010term regulation of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:roman>AQP2<\/jats:roman>\n                    <\/jats:styled-content>\n                    trafficking to and from the apical plasma membrane, and (2) long\u2010term regulation of the total abundance of the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:roman>AQP2<\/jats:roman>\n                    <\/jats:styled-content>\n                    protein in the cells. Most disorders of water balance are the result of dysregulation of processes that regulate the total abundance of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:roman>AQP2<\/jats:roman>\n                    <\/jats:styled-content>\n                    in collecting duct cells. In general, the level of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:roman>AQP2<\/jats:roman>\n                    <\/jats:styled-content>\n                    in a collecting duct cell is determined by a balance between production via translation of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:roman>AQP2<\/jats:roman>\n                    <\/jats:styled-content>\n                    m\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    and removal via degradation or secretion into the urine in exosomes.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:roman>AQP2<\/jats:roman>\n                    <\/jats:styled-content>\n                    abundance increases in response to vasopressin chiefly due to increased translation subsequent to increases in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:roman>AQP2<\/jats:roman>\n                    <\/jats:styled-content>\n                    m\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    . Vasopressin\u2010mediated regulation of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>AQP2<\/jats:italic>\n                    <\/jats:styled-content>\n                    gene transcription is poorly understood, although several transcription factor\u2010binding elements in the 5\u2032 flanking region of the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>AQP2<\/jats:italic>\n                    <\/jats:styled-content>\n                    gene have been identified, and candidate transcription factors corresponding to these elements have been discovered in proteomics studies. Here, we review progress in this area and discuss elements of vasopressin signaling in the collecting duct that may impinge on regulation of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:roman>AQP2<\/jats:roman>\n                    <\/jats:styled-content>\n                    in health and in the context of examples of polyuric diseases.\n                  <\/jats:p>","DOI":"10.1111\/j.1939-165x.2012.00488.x","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T10:56:22Z","timestamp":1352199382000},"page":"455-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Aquaporin\u20102 regulation in health and disease"],"prefix":"10.1111","volume":"41","author":[{"given":"M.","family":"Judith Radin","sequence":"first","affiliation":[{"name":"Department of Veterinary Biosciences College of Veterinary Medicine, The Ohio State University 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