{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:47:29Z","timestamp":1770155249088,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serum C-terminal atrial natriuretic peptide (CT-ANP) and N-terminal pro B-type natriuretic peptide (NT-pro BNP) concentrations have not been measured serially in dogs with chronic pressure overload of the heart.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>We investigated whether serial evaluation of CT-ANP and NT-pro BNP concentrations is a useful guide to the risk of cardiac remodeling in dogs with a model of aortic stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Six male Beagles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>After anesthesia, the aorta was constricted with a polyester band and mean left ventricular systolic pressure (LVPs) was 50\u2003mmHg above baseline. Echocardiographic and intracardiac catheter examinations and blood sampling were performed before surgery and 3 and 6 months after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LVP and left ventricular end-diastolic pressure (LVEDP) were significantly higher at 6 months. Compared with baseline, end-diastolic intraventricular septum thickness (IVSd), left ventricular posterior wall thickness (LVPWd), and relative wall thickness (RWT) were significantly increased 3 and 6 months after aortic constriction. Serum CT-ANP concentrations were increased significantly at 3 months and serum NT-pro BNP concentrations were significantly higher 3 and 6 months after aortic constriction. Serum NT-pro BNP concentration was significantly correlated with LVEDP and IVSd whereas serum CT-ANP concentration was not correlated with any measurement. Stepwise regression analysis showed that LVEDP, IVSd, and RWT could predict serum NT-pro BNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>This study indicated the differential regulation of NT-pro BNP and CT-ANP concentrations during pressure overload. NT-pro BNP assay may be used as an additional screening method to stratify early-stage ventricular remodeling because of aortic constriction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2008.0161.x","type":"journal-article","created":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T12:14:09Z","timestamp":1232626449000},"page":"1118-1123","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of NT-Pro BNP and CT-ANP as Markers of Concentric Hypertrophy in Dogs with a Model of Compensated Aortic Stenosis"],"prefix":"10.1093","volume":"22","author":[{"given":"Y.","family":"Hori","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University, Towada Laboratory of Small Animal Internal Medicine, , Aomori,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tsubaki","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University, Towada Laboratory of Small Animal Internal Medicine, , Aomori,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Katou","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University, Towada Laboratory of Small Animal Internal Medicine, , Aomori,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Ono","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University, Towada Laboratory of Small Animal Internal Medicine, , Aomori,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yonezawa","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University, Towada Laboratory of Veterinary Physiology, , Aomori,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Jilin University, Chang Chun City Laboratory of Animal Nutritional and Metabolic Diseases and Toxicopathy, , Jilin Province,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.-I.","family":"Higuchi","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kitasato University, Towada Laboratory of Small Animal Internal Medicine, , Aomori,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,9,1]]},"reference":[{"key":"2026020304250904400_b1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1939-1676.2007.0007.x","article-title":"Evaluation of plasma C-terminal atrial natriuretic peptide in healthy cats and cats with heart 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