{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:54:33Z","timestamp":1793235273463,"version":"4.5.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A mutation in the sarcomeric gene coding for the myosin-binding protein C gene has been identified in a colony of Maine Coon cats with hypertrophic cardiomyopathy (MyBPC3-A31P mutation). However, the close correlation between genotype and phenotype (left ventricular hypertrophy [LVH] and dysfunction) has never been assessed in a large population, particularly in heterozygous (Hetero) cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate LV morphology and function with echocardiography and tissue Doppler imaging (TDI) in a population of Maine Coon cats tested for the MyBPC3-A31P mutation with focus on Hetero animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ninety-six Maine Coon cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational study. Cats were screened for the MyBPC3-A31P mutation and examined with both echocardiography and 2-dimensional color TDI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-two out of 96 cats did not have the mutation (wild-type genotype, Homo WT), 38\/96 and 6\/96 were Hetero- and homozygous-mutated (Homo M) cats, respectively. Only 11% of Hetero cats (4\/38) had LVH and 29% (10\/34) of Hetero cats without LVH were &amp;gt;4 years old (4.1\u201311.5 years). LVH was also detected in 2 Homo WT cats (4%). A significantly decreased (P &amp;lt; .05) longitudinal E\/A (ratio between early and late diastolic myocardial velocities) in the basal segment of the interventricular septum was observed in Hetero cats without LVH (n = 34) compared with Homo WT cats without LVH (n = 50), thus confirming that the Hetero status is associated with regional diastolic dysfunction (P &amp;lt; .05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The heterozygous status is not consistently associated with LVH and major myocardial dysfunction. Moreover, Homo WT cats can also develop LVH, suggesting that other genetic causes might be implicated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2008.0218.x","type":"journal-article","created":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T13:52:23Z","timestamp":1227102743000},"page":"91-99","source":"Crossref","is-referenced-by-count":60,"title":["Prospective Echocardiographic and Tissue Doppler Imaging Screening of a Population of Maine Coon Cats Tested for the A31P Mutation in the Myosin-Binding Protein C Gene: A Specific Analysis of the Heterozygous Status"],"prefix":"10.1093","volume":"23","author":[{"given":"C.","family":"Carlos Sampedrano","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Cardiologie d'Alfort , Maisons-Alfort,","place":["France"]},{"name":"UMR INSERM ENVA U841 (Institut National de la Sant\u00e9 et la Recherche M\u00e9dicale) , Maisons-Alfort,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Chetboul","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Cardiologie d'Alfort , Maisons-Alfort,","place":["France"]},{"name":"UMR INSERM ENVA U841 (Institut National de la Sant\u00e9 et la Recherche M\u00e9dicale) , Maisons-Alfort,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mary","sequence":"additional","affiliation":[{"name":"UMR 955, G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, \u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort , Maisons-Alfort,","place":["France"]},{"name":"ANTAGENE, Laboratoire de Recherche et d'Analyses en G\u00e9nomique Animale , Limonest,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Tissier","sequence":"additional","affiliation":[{"name":"UMR INSERM ENVA U841 (Institut National de la Sant\u00e9 et la Recherche M\u00e9dicale) , Maisons-Alfort,","place":["France"]},{"name":"Unit\u00e9 de Pharmacie-Toxicologie , Maisons-Alfort,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Abitbol","sequence":"additional","affiliation":[{"name":"UMR 955, G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, \u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort , Maisons-Alfort,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Serres","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Cardiologie d'Alfort , Maisons-Alfort,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Gouni","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Cardiologie d'Alfort , Maisons-Alfort,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Thomas","sequence":"additional","affiliation":[{"name":"ANTAGENE, Laboratoire de Recherche et d'Analyses en G\u00e9nomique Animale , Limonest,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-L.","family":"Pouchelon","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Cardiologie d'Alfort , Maisons-Alfort,","place":["France"]},{"name":"UMR INSERM ENVA U841 (Institut National de la Sant\u00e9 et la Recherche M\u00e9dicale) , Maisons-Alfort,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,1,1]]},"reference":[{"key":"2026020304280134600_b1","first-page":"1227","article-title":"Feline hypertrophic cardiomyopathy","volume":"34","author":"Baty","year":"2004","journal-title":"An update"},{"key":"2026020304280134600_b2","first-page":"346","volume-title":"Small Animal Cardiovascular Medicine","author":"Kittleson","year":"1998","edition":"2nd ed"},{"key":"2026020304280134600_b3","first-page":"621","volume-title":"Textbook of Canine and Feline Cardiology","author":"Fox","year":"1999","edition":"2nd ed"},{"key":"2026020304280134600_b4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1760-2734(06)70051-0","article-title":"Hypertrophic cardiomyopathy. 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