{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T21:00:31Z","timestamp":1770843631036,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glomerular filtration rate (GFR) is decreased in humans with hypothyroidism, but information about kidney function in dogs with hypothyroidism is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Hypothyroidism influences GFR in dogs. The objective of this study was to assess GFR in hypothyroid dogs before implementation of thyroxine supplementation and after re-establishing euthyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Fourteen hypothyroid dogs without abnormalities on renal ultrasound examination or urinalysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blood pressure and GFR (measured by exogenous creatinine clearance) were measured before treatment (T0, n = 14) and at 1 month (T1, n = 14) and at 6 months (T6, n = 11) after beginning levothyroxine supplementation therapy (20\u2003\u03bcg\/kg\/d, PO). The response to therapy was monitored at T1 by measuring serum total thyroxine and thyroid stimulating hormone concentrations. If needed, levothyroxine dosage was adjusted and reassessed after 1 month. Statistical analysis was performed using a general linear model. Results are expressed as mean \u00b1 standard deviation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At T0, the average age of dogs in the study group was 6.3 \u00b1 1.4 years. Their average body weight decreased from 35 \u00b1 18\u2003kg at T0 to 27 \u00b1 14\u2003kg at T6 (P &amp;lt; .05). All dogs remained normotensive throughout the study. GFR increased significantly with levothyroxine supplementation; the corresponding results were 1.6 \u00b1 0.4\u2003mL\/min\/kg at T0, 2.1 \u00b1 0.4 at T1, and 2.0 \u00b1 0.4 at T6 (P &amp;lt; .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GFR was &amp;lt;2 mL\/min\/kg in untreated hypothyroid dogs. Re-establishment of a euthyroid state increased GFR significantly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2009.0331.x","type":"journal-article","created":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T15:51:42Z","timestamp":1243871502000},"page":"844-849","source":"Crossref","is-referenced-by-count":30,"title":["Effect of Thyroxine Supplementation on Glomerular Filtration Rate in Hypothyroid Dogs"],"prefix":"10.1093","volume":"23","author":[{"given":"K.","family":"Gommeren","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Ghent University Department of Small Animal Medicine and Clinical Biology, , Merelbeke,","place":["Belgium"]},{"name":"Internal Medicine of Small Animals, Veterinary Faculty, University of Li\u00e8ge Department of Clinical Sciences, , Li\u00e8ge,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Van Hoek","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Ghent University Department of Small Animal Medicine and Clinical Biology, , Merelbeke,","place":["Belgium"]},{"name":"Royal Canin Centre R&D , Aimargues,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.P.","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"ENVT, \u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse Department of Clinical Sciences and UMR181 of Physiopathology and Experimental Toxicology INRA, , Toulouse Cedex,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Benchekroun","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, \u00c9cole Nationale V\u00e9t\u00e9rinaire d'Alfort , Maisons-Alfort Cedex,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Smets","sequence":"additional","affiliation":[{"name":"Faculty of 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