{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:41:58Z","timestamp":1770216118493,"version":"3.49.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite many epidemiological reports concerning the efficacy of angiotensin-converting enzyme (ACE) inhibitors in dogs with mitral regurgitation (MR), the hemodynamic effects of ACE inhibitor administration have not been fully evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To document left atrial pressure (LAP) in dogs with MR administered ACE inhibitors, in order to obtain interesting information about daily LAP changes with administration of ACE inhibitors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Five healthy Beagle dogs weighing 9.8 to 14.2\u2003kg (2 males and 3 females; aged 2 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Experimental, crossover, and interventional study. Chordae tendineae rupture was induced, and a radiotelemetry transmitter catheter was inserted into the left atrium. LAP was recorded for 72 consecutive hours during which each of 3 ACE inhibitors\u2014enalapril (0.5\u2003mg\/kg\/d), temocapril (0.1\u2003mg\/kg\/d), and alacepril (3.0\u2003mg\/kg\/d)\u2014were administered in a crossover study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Averaged diurnal LAP was significantly, but slightly reduced by alacepril (P= .03, 19.03 \u00b1 3.01\u201318.24 \u00b1 3.07\u2003mmHg). The nightly drops in LAP caused by alacepril and enalapril were significantly higher than the daily drops (P= .03, \u22120.98 \u00b1 0.19 to \u22120.07 \u00b1 0.25\u2003mmHg, and P= .03, \u22120.54 \u00b1 0.21\u20130.02 \u00b1 0.17\u2003mmHg, respectively), despite the fact that the oral administrations were given in the morning. Systolic blood pressure (122.7 \u00b1 14.4\u2013117.4 \u00b1 13.1\u2003mmHg, P= .04) and systemic vascular resistance (5800 \u00b1 2685\u20135144 \u00b1 2077\u2003dyne \u00d7 s\/cm5, P= .03) were decreased by ACE inhibitors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>ACE inhibitors decrease LAP minimally, despite reductions in left ventricular afterload. ACE inhibitors should not be used to decrease LAP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2009.0455.x","type":"journal-article","created":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T15:00:38Z","timestamp":1264431638000},"page":"342-347","source":"Crossref","is-referenced-by-count":17,"title":["The Effect of Angiotensin-Converting Enzyme Inhibitors of Left Atrial Pressure in Dogs with Mitral Valve Regurgitation"],"prefix":"10.1093","volume":"24","author":[{"given":"T.","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology Department of Veterinary Surgery, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology Department of Veterinary Surgery, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology Department of Veterinary Surgery, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Miyaishi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology Department of Veterinary Surgery, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Akagi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology Department of Veterinary Surgery, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Iino","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology Department of Veterinary Surgery, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology Department of Veterinary Surgery, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yamane","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology Department of Veterinary Surgery, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,3,1]]},"reference":[{"key":"2026020303142088900_b1","first-page":"110","article-title":"Manual of Canine and Feline Cardiology","author":"Abott","year":"2008","edition":"4th 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