{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:47:48Z","timestamp":1770220068565,"version":"3.49.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>An assay for the measurement of pancreatic elastase in dog feces has been introduced.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>The goal of this study was to evaluate the rate of false-positive fecal-elastase test results in dogs with suspected exocrine pancreatic insufficiency (EPI) and to assess serum cholecystokinin (CCK) concentrations in dogs with a false positive fecal elastase test result.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty-six fecal and serum samples from dogs suspected of EPI, for which samples had been submitted to a commercial laboratory (Vet Med Labor) for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective study. Serum trypsin-like immunoreactivity (TLI) was measured in 26 dogs with a decreased fecal elastase concentration of &amp;lt;10\u2003\u03bcg\/g feces. Serum CCK concentrations were measured in 21 of these dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 26 dogs with a decreased fecal elastase concentration, 6 (23%) had serum TLI concentrations within or above the reference range. Serum CCK concentrations were significantly higher in dogs with a true positive fecal elastase test result (median: 1.1\u2003pmol\/L; range: 0.1\u20133.3\u2003pmol\/L) than in those with a false positive fecal elastase test result (median: 0.1\u2003pmol\/L; range: 0.1\u20130.9\u2003pmol\/L; P value = .0163).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>The rate of false positive fecal elastase test results was high in this group of dogs, suggesting that diagnosis of EPI must be confirmed by other means. The decreased CCK concentration in dogs with a false positive fecal elastase test result could suggest that false positive results are because of decreased stimulation of exocrine pancreatic function caused by other conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2010.0489.x","type":"journal-article","created":{"date-parts":[[2010,3,15]],"date-time":"2010-03-15T13:16:56Z","timestamp":1268659016000},"page":"643-646","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of Fecal Elastase and Serum Cholecystokinin in Dogs with a False Positive Fecal Elastase Test"],"prefix":"10.1093","volume":"24","author":[{"given":"J.M.","family":"Steiner","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, , College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.F.","family":"Rehfeld","sequence":"additional","affiliation":[{"name":"Rigshospitalet, University of Copenhagen Department of Clinical Biochemistry, , Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Pantchev","sequence":"additional","affiliation":[{"name":"Vet Med Labor GmbH, Division of IDEXX Laboratories , Ludwigsburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,5,1]]},"reference":[{"key":"2026020303150007600_b1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2460\/javma.1988.192.02.195","article-title":"Sensitivity and specificity of radioimmunoassay of serum trypsin-like immunoreactivity for the diagnosis of canine exocrine pancreatic insufficiency","volume":"192","author":"Williams","year":"1988","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303150007600_b2","first-page":"1","article-title":"Canine faecal pancreatic elastase (cE1) in dogs with clinical exocrine pancreatic insufficiency, normal dogs and dogs with chronic enteropathies","volume":"5","author":"Spillmann","year":"2000","journal-title":"Eur J Comp Gastroenterol"},{"key":"2026020303150007600_b3","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1055\/s-2004-813604","article-title":"The diagnostic validity of non-invasive pancreatic function tests\u2013a meta-analysis","volume":"42","author":"Siegmund","year":"2004","journal-title":"Z Gastroenterol"},{"key":"2026020303150007600_b4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1939-165X.2005.tb00009.x","article-title":"Effect of intestinal inflammation on fecal elastase concentration in dogs","volume":"34","author":"Battersby","year":"2005","journal-title":"Vet Clin Pathol"},{"key":"2026020303150007600_b5","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/clinchem\/44.5.991","article-title":"Accurate measurement of cholecystokinin in plasma","volume":"44","author":"Rehfeld","year":"1998","journal-title":"Clin Chem"},{"key":"2026020303150007600_b6","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2460\/javma.2002.220.1183","article-title":"Subclinical exocrine pancreatic insufficiency in dogs","volume":"220","author":"Wiberg","year":"2002","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303150007600_b7","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/j.1939-1676.2007.tb03073.x","article-title":"Suspected isolated pancreatic lipase deficiency in a dog","volume":"21","author":"Xenoulis","year":"2007","journal-title":"J Vet Interm Med"},{"key":"2026020303150007600_b8","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2460\/javma.1990.196.04.623","article-title":"High serum trypsin-like immunoreactivity secondary to pancreatitis in a dog with exocrine pancreatic insufficiency","volume":"196","author":"Keller","year":"1990","journal-title":"J Am Vet Med Assoc"},{"key":"2026020303150007600_b9","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1748-5827.2003.tb00159.x","article-title":"Exocrine pancreatic insufficiency as an end stage of pancreatitis in four dogs","volume":"44","author":"Watson","year":"2003","journal-title":"J Small Anim Pract"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1939-1676.2010.0489.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/24\/3\/643\/66654182\/j.1939-1676.2010.0489.x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/24\/3\/643\/66654182\/j.1939-1676.2010.0489.x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T08:15:07Z","timestamp":1770106507000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/24\/3\/643\/8447240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,1]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,5,1]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1939-1676.2010.0489.x","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,5]]},"published":{"date-parts":[[2010,5,1]]}}}