{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:59:17Z","timestamp":1770220757386,"version":"3.49.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Canine Control Council (QLD)'s Breeders' Research Grants"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertriglyceridemia has been proposed to contribute to the risk of developing pancreatitis in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine associations between postprandial serum triglyceride concentrations and canine pancreatic lipase immunoreactivity (cPLI) concentrations or pancreatic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty-five client-owned overweight (n\u00a0=\u00a025) or obese (n\u00a0=\u00a010) dogs weighing &amp;gt;10\u00a0kg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Healthy dogs were prospectively recruited for a cross-sectional study. Serum triglyceride concentrations were measured before and hourly for 12\u00a0hours after a meal. Fasting cPLI and canine trypsin-like immunoreactivity (cTLI) concentrations were assayed. Cut-off values for hypertriglyceridemia were set a priori for fasting (\u226588, \u2265177, \u2265354, \u2265885\u00a0mg\/dL) and peak postprandial (\u2265133, \u2265442, \u2265885\u00a0mg\/dL) triglyceride concentrations. The association between hypertriglyceridemia and high cPLI concentrations was assessed by exact logistic regression. Follow-up was performed 4\u00a0years later to determine the incidence of pancreatic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight dogs had peak postprandial triglycerides &amp;gt;442\u00a0mg\/dL and 3 dogs had fasting serum cPLI concentrations \u2265400\u00a0\u03bcg\/L. Odds of high cPLI concentrations were 16.7 times higher in dogs with peak postprandial triglyceride concentrations \u2265442\u00a0mg\/dL relative to other dogs (P\u00a0&amp;lt;\u00a0.001). Fasting triglyceride concentration was not significantly associated with cPLI concentrations. None of the dogs with high triglyceride concentrations and one of the dogs with low fasting and peak postprandial triglyceride concentrations developed clinically important pancreatic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Overweight and obese dogs with peak serum postprandial triglyceride concentrations \u2265442\u00a0mg\/dL after a standard meal are more likely to have serum cPLI concentrations \u2265400\u00a0\u03bcg\/L, but did not develop clinically important pancreatic disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2011.00844.x","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T15:21:20Z","timestamp":1326208880000},"page":"46-53","source":"Crossref","is-referenced-by-count":23,"title":["Association of Postprandial Serum Triglyceride Concentration and Serum Canine Pancreatic Lipase Immunoreactivity in Overweight and Obese Dogs"],"prefix":"10.1093","volume":"26","author":[{"given":"K.R.","family":"Verkest","sequence":"first","affiliation":[{"name":"Centre for Companion Animal Health, School of Veterinary Science, The University of Queensland , Gatton, QLD, 4072","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.M.","family":"Fleeman","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, The University of Queensland , St Lucia, QLD, 4343","place":["Australia"]},{"name":"Animal Diabetes Australia , Boronia, Victoria, 3155","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Morton","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, The University of Queensland , St Lucia, QLD, 4343","place":["Australia"]},{"name":"Jemora Pty Ltd , Geelong, Victoria, 3220","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.J.","family":"Groen","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, The University of Queensland , St Lucia, QLD, 4343","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.S.","family":"Suchodolski","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Texas A&M University , College Station, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Texas A&M University , College Station, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.S.","family":"Rand","sequence":"additional","affiliation":[{"name":"Centre for Companion Animal Health, School of Veterinary Science, The University of Queensland , Gatton, QLD, 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