{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:24:54Z","timestamp":1791638694286,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Clinical assessment of metabolic acidosis in calves with neonatal diarrhea can be difficult because increased blood concentrations of d-lactate and not acidemia per se are responsible for most of the clinical signs exhibited by these animals.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To describe the correlation between clinical and laboratory findings and d-lactate concentrations. Furthermore, the theoretical outcome of a simplified treatment protocol based on posture\/ability to stand and degree of dehydration was evaluated.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n A total of 121 calves with diagnosis of neonatal diarrhea admitted to a veterinary teaching hospital during an 8-month study period.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Prospective blinded cohort study. Physical examinations were carried out following a standardized protocol. Theoretical outcome of treatment was calculated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Type and degree of metabolic acidosis were age dependent. The clinical parameters posture, behavior, and palpebral reflex were closely correlated to base excess (r\u00a0=\u00a00.74, 0.78, 0.68; P\u00a0&lt;\u00a0.001) and d-lactate concentrations (r\u00a0=\u00a00.59, 0.59, 0.71; P\u00a0&lt;\u00a0.001), respectively. Thus, determining the degree of loss of the palpebral reflex was identified as the best clinical tool for diagnosing increase in serum d-lactate concentrations. Theoretical outcome of treatment revealed that the tested dosages of sodium bicarbonate are more likely to overdose than to underdose calves with diarrhea and metabolic acidosis.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Importance<\/jats:title>\n The degree of metabolic acidosis in diarrheic calves can be predicted based on clinical findings. The assessed protocol provides a useful tool to determine bicarbonate requirements, but a revision is necessary for calves with ability to stand and marked metabolic acidosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2011.00848.x","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T00:39:17Z","timestamp":1323823157000},"page":"162-170","source":"Crossref","is-referenced-by-count":40,"title":["Metabolic Acidosis in Neonatal Calf Diarrhea\u2014Clinical Findings and Theoretical Assessment of a Simple Treatment Protocol"],"prefix":"10.1093","volume":"26","author":[{"given":"F.M.","family":"Trefz","sequence":"first","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, LMU Munich , Oberschlei\u00dfheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lorch","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, LMU Munich , Oberschlei\u00dfheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Feist","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, LMU Munich , Oberschlei\u00dfheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sauter-Louis","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, LMU Munich , Oberschlei\u00dfheim,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Lorenz","sequence":"additional","affiliation":[{"name":"UCD School of Veterinary Medicine, University College Dublin , 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