{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:40:30Z","timestamp":1790221230360,"version":"4.1.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Trigeminal neuralgia or neuropathic pain has been regarded as a putative cause of idiopathic headshaking in horses. Equine herpesvirus-1 (EHV-1) infection and resultant postherpetic pain have been suggested as a possible cause of such neuropathic pain.<\/jats:p>\n <\/jats:sec>\n \n Hypothesis\/Objectives<\/jats:title>\n To determine the presence of EHV-1 in the trigeminal ganglia of horses with idiopathic headshaking.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Nineteen horses: control (n\u00a0=\u00a011, 9 geldings, 2 mares, median age 11\u00a0years) and headshaking (n\u00a0=\u00a08, all geldings, median age 11.5\u00a0years) horses were sourced from the equine research herd and caseload at the Veterinary Medical Teaching Hospital.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Prospective study to determine the presence of EHV-1 latency in trigeminal ganglia of horses with idiopathic headshaking by real-time PCR detection of the glycoprotein B (gB) gene and the DNA polymerase (ORF 30) gene of EHV-1 in the absence of detectable late structural protein gene (gB gene) mRNA. Control horses were used for comparison. A house keeping gene (equine GAPDH) and positive and negative samples for EHV-1 were used for quality control.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n All samples from control horses and 7 of 8 headshaking horses were negative for EHV-1. One headshaking horse tested positive for a single copy of EHV-1 gene.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Importance<\/jats:title>\n This study does not support a role for EHV-1 infection and presumed postherpetic pain in the etiopathogenesis of equine headshaking.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2011.00855.x","type":"journal-article","created":{"date-parts":[[2011,12,24]],"date-time":"2011-12-24T19:01:37Z","timestamp":1324753297000},"page":"192-194","source":"Crossref","is-referenced-by-count":22,"title":["Latent Equine Herpesvirus-1 in Trigeminal Ganglia and Equine Idiopathic Headshaking"],"prefix":"10.1093","volume":"26","author":[{"given":"M.","family":"Aleman","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, University of California Davis Department of Medicine and Epidemiology, , Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.J.","family":"Pickles","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California Davis Department of Medicine and Epidemiology, , Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Simonek","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California Davis Department of Medicine and Epidemiology, , Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Madigan","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California Davis Department of Medicine and Epidemiology, , Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"2026020303571376200_jvim855-bib-0001","first-page":"321","article-title":"Involuntary shaking of the 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