{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:59:54Z","timestamp":1792450794758,"version":"4.5.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Idiopathic pulmonary fibrosis (IPF) is a chronic, interstitial lung disease primarily affecting West Highland White Terriers (WHWTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the clinicopathological and diagnostic imaging features in WHWTs with IPF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twelve WHWTs with IPF and 14 healthy control WHWTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Prospective study. Clinical signs and findings of physical examination, blood and arterial blood gas analyses, radiography, high-resolution computed tomography (HRCT), bronchoscopy and bronchoalveolar lavage (BAL) of IPF dogs were obtained and compared with controls. Histopathologic changes in IPF dogs were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean partial pressure of oxygen was significantly lower in IPF (mean \u00b1 SD, 65.5 \u00b1 15.4\u2003mmHg) than in controls (99.1 \u00b1 7.8\u2003mmHg, P&amp;lt;.001). The alveolar-arterial oxygen gradient was significantly higher in IPF (50.1 \u00b1 17.3\u2003mmHg) than in controls (17.5 \u00b1 4.9\u2003mmHg, P&amp;lt;.001). In HRCT, ground glass opacity (GGO) was detected in all IPF dogs, traction bronchiectasis in 4, and honeycombing in 1. Bronchoscopic airway changes were noted in all IPF dogs. On BAL fluid (BALF) cytology, the total cell count (TCC) was higher in IPF dogs, and the numbers but not the percentages of macrophages, neutrophils, and mast cells were increased. On histopathology, multifocal or diffuse interstitial fibrosis, type II pneumocyte hyperplasia, prominent intraalveolar macrophages, distortion of alveolar architecture, and emphysematous change were detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>IPF causes substantial hypoxemia. In HRCT, GGO is a consistent finding. IPF dogs have concurrent airway changes and an increase in BALF TCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2011.0694.x","type":"journal-article","created":{"date-parts":[[2011,3,2]],"date-time":"2011-03-02T22:20:32Z","timestamp":1299104432000},"page":"433-439","source":"Crossref","is-referenced-by-count":71,"title":["Clinical, Bronchoscopic, Histopathologic, Diagnostic Imaging, and Arterial Oxygenation Findings in West Highland White Terriers with Idiopathic Pulmonary Fibrosis"],"prefix":"10.1093","volume":"25","author":[{"given":"H.P.","family":"Heikkil\u00e4","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Helsinki Department of Equine and Small Animal Medicine, , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.K.","family":"Lappalainen","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Helsinki Department of Equine and Small Animal Medicine, , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Day","sequence":"additional","affiliation":[{"name":"School of Veterinary Sciences, University of Bristol , Bristol,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Clercx","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Li\u00e8ge Department of Clinical Sciences, , Li\u00e8ge, Belgium (Clercx)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Rajam\u00e4ki","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Helsinki Department of Equine and Small Animal Medicine, , Helsinki,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"key":"2026020303445284700_b1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1440-1843.2009.01624.x","article-title":"Determinants of initiation and progression of idiopathic pulmonary fibrosis","volume":"14","author":"Kottmann","year":"2009","journal-title":"Respirology"},{"key":"2026020303445284700_b2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/vr.144.22.611","article-title":"Chronic pulmonary disease in West Highland White Terriers","volume":"144","author":"Corcoran","year":"1999","journal-title":"Vet Rec"},{"key":"2026020303445284700_b3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5326\/15473317-37-2-119","article-title":"Chronic idiopathic pulmonary fibrosis in five dogs","volume":"37","author":"Lobetti","year":"2001","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026020303445284700_b4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1354\/vp.42-1-35","article-title":"Interstitial lung disease in West Highland White Terriers","volume":"42","author":"Norris","year":"2005","journal-title":"Vet Pathol"},{"key":"2026020303445284700_b5","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/j.1939-1676.2009.0380.x","article-title":"Surfactant protein C in canine pulmonary fibrosis","volume":"23","author":"Erikson","year":"2009","journal-title":"J Vet Intern Med"},{"key":"2026020303445284700_b6","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1378\/chest.125.6.2278","article-title":"Identification of spontaneous feline idiopathic pulmonary fibrosis\u2014morphology and ultrastructural evidence for a type II pneumocyte defect","volume":"125","author":"Williams","year":"2004","journal-title":"Chest"},{"key":"2026020303445284700_b7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1164\/ajrccm.161.2.ats3-00","article-title":"Idiopathic pulmonary fibrosis: Diagnosis and treatment. 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