{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:54:25Z","timestamp":1770220465098,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastric ulcers are common in horses and treatment of horses that cannot be administered oral medication can be problematic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the efficacy of esomeprazole sodium administered intravenously on gastric juice pH and gastric ulcer scores in horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twelve adult female Quarter Horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Esomeprazole sodium (0.5\u2003mg\/kg IV) was administered once daily to 8 horses (treatment group) and saline (5\u2003mL IV) was administered to 4 horses (control group) for 13 consecutive days. Gastroscopy was performed and gastric juice pH and gastric ulcer score were recorded before and 1 hour after the administration of esomeprazole sodium or saline on days 1 and 5, then on day 14, 23 hours after the 13th daily dose of esomeprazole sodium or saline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When compared with values before treatment, gastric juice pH was higher in esomeprazole sodium-treated horses after treatment (4.25 \u00b1 2.39 versus 6.43 \u00b1 1.18; P= .002). Also, gastric juice pH was higher (P= .001) in esomeprazole sodium-treated horses compared with saline-treated control horses on day 5 and on day 14 values. Gastric ulcers were seen in 5\/12 (43%) horses in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Esomeprazole sodium shows promise for treatment of gastric ulcers in horses with signs of dysphagia, gastric reflux, or other conditions that restrict oral intake of the current Federal Drug Administration-approved omeprazole paste.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2011.0716.x","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T13:37:20Z","timestamp":1301665040000},"page":"558-562","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Intravenously Administered Esomeprazole Sodium on Gastric Juice pH in Adult Female Horses"],"prefix":"10.1093","volume":"25","author":[{"given":"R.","family":"Videla","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, University of Tennessee Department of Large Animal Clinical Sciences, , Knoxville, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.S.","family":"Sommardahl","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Tennessee Department of Large Animal Clinical Sciences, , Knoxville, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.B.","family":"Elliott","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Tennessee Department of Large Animal Clinical Sciences, , Knoxville, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vasili","sequence":"additional","affiliation":[{"name":"Randlab Australia Pty Ltd ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.M.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Equine Heath Studies Program , Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"key":"2026020303443209600_b1","first-page":"122","article-title":"Recommendations for the diagnosis and treatment of equine gastric ulcer syndrome (EGUS)","volume":"1","author":"Anon","year":"1999","journal-title":"Equine Vet Educ"},{"issue":"3","key":"2026020303443209600_b2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.2042-3306.1999.tb05166.x","article-title":"Cross-sectional study of gastric ulcers of the squamous mucosa in Thoroughbred racehorses","volume":"29","author":"Vatistas","year":"1999","journal-title":"Equine Vet J"},{"key":"2026020303443209600_b3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.cveq.2009.04.013","article-title":"New perspectives in equine gastric ulcer syndrome","volume":"25","author":"Videla","year":"2009","journal-title":"Vet Clin North Am Equine Pract"},{"key":"2026020303443209600_b4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.2042-3306.1996.tb03107.x","article-title":"Factors associated with gastric lesions in Thoroughbred racehorses","volume":"28","author":"Murray","year":"1996","journal-title":"Equine Vet J"},{"key":"2026020303443209600_b5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.tvjl.2008.03.020","article-title":"Prevalence of gastric ulcers in Thoroughbred broodmares in pasture: A preliminary report","volume":"181","author":"Le Jeune","year":"2009","journal-title":"Vet J"},{"issue":"3","key":"2026020303443209600_b6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1365-2036.2004.02163.x","article-title":"Review article. pH, healing and symptom relief with rabeprazole treatment in acid-related disorders","volume":"20","author":"Robinson","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"2026020303443209600_b7","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2746\/042516401776563517","article-title":"Histological characteristics of induced acute peptic injury in equine gastric squamous epithelium","volume":"33","author":"Murray","year":"2001","journal-title":"Equine Vet J"},{"key":"2026020303443209600_b8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cveq.2003.08.012","article-title":"Treatment and prevention of equine gastric ulcer syndrome","volume":"19","author":"Buchanan","year":"2003","journal-title":"Vet Clin North Am Equine Pract"},{"key":"2026020303443209600_b9","first-page":"1503","article-title":"Esomeprazole. A review of its use in the management of acid-related disorders","volume":"62","author":"Scott","year":"2002","journal-title":"Adis Drug Eval"},{"key":"2026020303443209600_b10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.18773\/austprescr.2004.039","article-title":"Inside the isomers: The tale of chiral switches","volume":"27","author":"Somogyi","year":"2004","journal-title":"Aust Prescriber (National Prescriber Service)"},{"key":"2026020303443209600_b11","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1023\/A:1015009300955","article-title":"Effect of esomeprazole 40\u2003mg vs omeprazole 40\u2003mg on 24-hour intragastric pH in patients with symptoms of gastroesophageal reflux disease","volume":"47","author":"Rohss","year":"2002","journal-title":"Dig Dis Sci"},{"key":"2026020303443209600_b12","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1046\/j.1365-2036.2000.00813.x","article-title":"Esomeprazole provides improved acid control vs. omeprazole in patients with symptoms of gastro-oesophageal reflux disease","volume":"14","author":"Lind","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"2026020303443209600_b13","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2165\/00003495-200060020-00006","article-title":"Esomeprazole","volume":"60","author":"Spencer","year":"2000","journal-title":"Drugs"},{"key":"2026020303443209600_b14","first-page":"411","article-title":"Pharmacokinetics studies with esomeprazole, the (S)-isomer of omeprazole","volume":"40","author":"Andersson","year":"2001","journal-title":"Drug Deposition"},{"key":"2026020303443209600_b15","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.jevs.2009.10.006","article-title":"Preliminary study of the gastric acidity in Thoroughbred horses at rest after enteral administration of esomeprazole magnesium (NEXIUM)","volume":"29","author":"Pereira","year":"2009","journal-title":"J Equine Vet Sci"},{"key":"2026020303443209600_b16","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/j.1939-1676.2006.tb00723.x","article-title":"Effects of intravenously administrated omeprazole on gastric juice pH and gastric ulcer scores in adult horses","volume":"20","author":"Andrews","year":"2006","journal-title":"J Vet Intern Med"},{"key":"2026020303443209600_b17","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.2042-3306.1997.tb03154.x","article-title":"A scoring system for gastric ulcers in the horse","volume":"29","author":"Macallister","year":"1997","journal-title":"Equine Vet J"},{"issue":"3","key":"2026020303443209600_b18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.2042-3306.1999.tb05171.x","article-title":"Effect of omeprazole paste on gastric acid secretion in horses","volume":"29","author":"Daurio","year":"1999","journal-title":"Equine Vet J"},{"issue":"3","key":"2026020303443209600_b19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.2042-3306.1992.tb04794.x","article-title":"Pharmacokinetics and antisecretory effects of intravenous omeprazole in horses","volume":"13","author":"Jenkins","year":"1992","journal-title":"Equine Vet J"},{"key":"2026020303443209600_b20","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1365-2885.2005.00690.x","article-title":"Pharmacodynamic study of a long-acting parenteral formulation of omeprazole in horses","volume":"28","author":"Tellez","year":"2005","journal-title":"J Vet Pharmacol Therap"},{"key":"2026020303443209600_b21","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2746\/042516402776117818","article-title":"The effects of xylazine, detomidine, acepromazine and butorphanol on equine solid phase gastric emptying rate","volume":"34","author":"Sutton","year":"2002","journal-title":"Equine Vet J"},{"key":"2026020303443209600_b22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1532-950X.1999.00375.x","article-title":"The effect of sedation on gastric emptying of a liquid marker in ponies","volume":"28","author":"Doherty","year":"1999","journal-title":"Vet Surg"},{"issue":"3","key":"2026020303443209600_b23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.2042-3306.1999.tb05161.x","article-title":"Normal equine gastroduodenal secretion and motility","volume":"29","author":"Merritt","year":"1999","journal-title":"Equine Vet J"},{"key":"2026020303443209600_b24","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1007\/BF02087686","article-title":"Equine model of inducing ulceration in alimentary squamous epithelial mucosa","volume":"39","author":"Murray","year":"1994","journal-title":"Dig Dis Sci"},{"key":"2026020303443209600_b25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.2042-3306.1993.tb02983.x","article-title":"Measurement of 24-h gastric pH using an indwelling pH electrode in horses unfed, fed and treated with ranitidine","volume":"25","author":"Murray","year":"1993","journal-title":"Equine Vet J"},{"key":"2026020303443209600_b26","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/archinte.159.7.649","article-title":"Importance of pH control in the management of GERD","volume":"159","author":"Hunt","year":"1999","journal-title":"Arch Intern Med"},{"key":"2026020303443209600_b27","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1746-6342.2006.00065.x","article-title":"Review article: Understanding the pharmacodynamics and pharmacokinetic differences between proton pump inhibitors\u2014focus on pKa and metabolism","volume":"2","author":"Horn","year":"2006","journal-title":"Aliment Pharmacol Ther Sym Ser"},{"key":"2026020303443209600_b28","doi-asserted-by":"crossref","first-page":"336","DOI":"10.2746\/0425164054529427","article-title":"Pharmacokinetics and pharmacodynamics of panoprazole in clinically normal neonatal foals","volume":"37","author":"Ryan","year":"2005","journal-title":"Equine Vet J"},{"key":"2026020303443209600_b29","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.2460\/javma.1999.215.08.1130","article-title":"Prevalence of gastric ulcers in show horses","volume":"215","author":"McClure","year":"1999","journal-title":"J Am Vet Med"},{"key":"2026020303443209600_b30","author":"Bertone"},{"key":"2026020303443209600_b31","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2746\/042516406777749164","article-title":"Prevalence of gastric squamous ulceration in horses with abdominal pain","volume":"38","author":"Dukti","year":"2006","journal-title":"Equine Vet J"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1939-1676.2011.0716.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/25\/3\/558\/66681753\/j.1939-1676.2011.0716.x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/25\/3\/558\/66681753\/j.1939-1676.2011.0716.x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T08:45:03Z","timestamp":1770108303000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/25\/3\/558\/8451222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,1]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,5,1]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1939-1676.2011.0716.x","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,5]]},"published":{"date-parts":[[2011,5,1]]}}}