{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:53:54Z","timestamp":1791266034544,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Intervet Pharma R & D SA"},{"name":"Direction G\u00e9n\u00e9rale de l'Enseignement et de la Recherche"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diagnosis of pituitary-dependent hyperadrenocorticism (PDH) in cats is challenging because there is no specific diagnostic test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objective<\/jats:title>\n                    <jats:p>The determination of plasma ACTH precursor (POMC and pro-ACTH) concentration might facilitate the diagnosis of PDH in cats. The aim of the study was to evaluate prospectively the plasma concentrations of ACTH precursors in a small cohort of cats with PDH and to estimate the value of this approach for diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Four groups of cats were included: group 1 (cats with PDH), group 2 (cats with diabetes mellitus but not hyperadrenocorticism (HAC)), group 3 (cats with diabetes mellitus and confirmed acromegaly but not HAC), and group 4 (healthy cats).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PDH diagnosis was based on clinical data, low-dose dexamethasone suppression test (LDDST), and adrenal and pituitary gland computed tomography (CT) scan. For groups 2, 3, and 4, hyperadrenocorticism was excluded by LDDST or urine cortisol:creatinine ratio (UCCR). An immunoluminometric assay was used to determine plasma concentrations of ACTH precursors in the 4 groups of cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Group 1 contained 9 cats (enlarged pituitary gland in 7\/9). Plasma ACTH precursor concentrations ranged from &amp;lt;53 to &amp;gt;1010\u00a0pmol\/L with 8\/9 concentrations \u2265229\u00a0pmol\/L. Groups 2, 3, and 4 included 13, 7, and 13 cats, respectively. Plasma ACTH precursor concentrations ranged from &amp;lt;53 to 96\u00a0pmol\/L in group 2, &amp;lt;53 to 72\u00a0pmol\/L in group 3, and &amp;lt;53 to 99\u00a0pmol\/L in group 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>High plasma concentration of ACTH precursors in cats (&amp;gt;100\u00a0pmol\/L) is highly suggestive of PDH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2012.00924.x","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T08:41:31Z","timestamp":1334047291000},"page":"575-581","source":"Crossref","is-referenced-by-count":13,"title":["Plasma ACTH Precursors in Cats with Pituitary-Dependent Hyperadrenocorticism"],"prefix":"10.1093","volume":"26","author":[{"given":"G.","family":"Benchekroun","sequence":"first","affiliation":[{"name":"Internal Medicine Unit, Universit\u00e9 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