{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:54:19Z","timestamp":1791266059556,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Increases of adrenal hormone concentrations other than cortisol have been reported in dogs with hyperadrenocorticism (HAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Measuring noncortisol adrenal hormone concentrations will help identify HAC in dogs. The objective was to determine plasma cortisol, androstenedione, estradiol, progesterone, testosterone, and 17-hydroxyprogesterone concentrations during ACTH stimulation testing of dogs with clinical signs of HAC to ascertain their utility in diagnosis of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ninety dogs with clinical findings consistent with HAC had ACTH stimulation tests performed. Results from 29 dogs were excluded from analysis because diagnoses were inconclusive for a variety of reasons. Results from 32 dogs with HAC and 29 dogs with disease other than HAC were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational study. Concentrations of adrenocortical hormones were determined before and 1\u00a0hour after injecting 5\u00a0\u03bcg\/kg ACTH IM. Diagnoses were determined by response to therapy, histopathology or both.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Post-ACTH cortisol (P\u00a0&amp;lt;\u00a0.001), progesterone (P\u00a0=\u00a0.001), and 17-hydroxyprogesterone (P\u00a0&amp;lt;\u00a0.001) concentrations were associated with a diagnosis of HAC. Sensitivity and specificity, respectively, for diagnosing HAC for post-ACTH cortisol were 84 and 59%, progesterone 88 and 55%, and 17-hydroxyprogesterone 91 and 59%, and for post-ACTH cortisol, progesterone and 17-hydroxyprogesterone combined were 88 and 55%. Of 5 dogs with HAC and normal post-ACTH cortisol concentrations, 5 had increased progesterone and 4 had increased 17-hydroxyprogesterone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Serum progesterone and 17-hydroxyprogesterone concentrations were useful to diagnose HAC in this study, but were not more sensitive or specific than cortisol concentration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2012.00959.x","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T13:20:24Z","timestamp":1340025624000},"page":"945-952","source":"Crossref","is-referenced-by-count":31,"title":["Concentrations of Noncortisol Adrenal Steroids in Response to ACTH in Dogs with Adrenal-Dependent Hyperadrenocorticism, Pituitary-Dependent Hyperadrenocorticism, and Nonadrenal Illness"],"prefix":"10.1093","volume":"26","author":[{"given":"W.E.","family":"Monroe","sequence":"first","affiliation":[{"name":"Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech Department of Small Animal Clinical Sciences, , Blacksburg, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.L.","family":"Panciera","sequence":"additional","affiliation":[{"name":"Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech Department of Small Animal Clinical Sciences, , Blacksburg, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.L.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech Department of Biomedical Sciences and Pathobiology, , Blacksburg, 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