{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:48:22Z","timestamp":1786787302472,"version":"build-2736575974"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Splenic fibrohistiocytic nodules (SFHN) are commonly diagnosed. It is suspected that these represent a heterogeneous group of malignant and nonmalignant diseases, separation of which could improve the ability of clinicians to prognosticate for dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Immunohistochemistry will differentiate histologic diagnoses within the group of SFHN; survival after splenectomy is associated with those histologic types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty-two dogs with SFHN treated by or under direction from veterinary oncologists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective case record analysis from dogs followed from splenectomy until death. Clinical, histopathologic, and immunohistochemistry data analyzed for an association with survival time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-two dogs had SFHN; grade 1 (2 dogs), grade 2 (9 dogs), and grade 3 (lymphoid percentage &amp;lt;40%; 21 dogs). Twenty-two dogs died, 10 were censored (9 alive median of 883\u00a0days after splenectomy). Median overall survival was 387\u00a0days, and grade 3 SFHN was positively associated with survival time as previously reported (P\u00a0&amp;lt;\u00a0.001). Of 31 available samples, dogs had diseases reclassified as nodular hyperplasia (13; 8 complex, 5 lymphoid including 2 marginal zone), lymphoma (4; 2 marginal zone lymphoma, 1 high grade B-cell lymphoma, and 1 marginal zone transitional to high grade B-cell lymphoma), 8 stromal sarcomas, and 6 histiocytic sarcomas. Dogs with histiocytic sarcoma had worse survival (median 74\u00a0days) than dogs with other diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Splenic histiocytic sarcoma is an aggressive disease; however, some dogs with stromal sarcomas had long survival times. The term SFHN is no longer warranted for this group of disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1939-1676.2012.00986.x","type":"journal-article","created":{"date-parts":[[2012,8,7]],"date-time":"2012-08-07T05:19:08Z","timestamp":1344316748000},"page":"1164-1168","source":"Crossref","is-referenced-by-count":26,"title":["Histologic and Immunohistochemical Review of Splenic Fibrohistiocytic Nodules in Dogs"],"prefix":"10.1093","volume":"26","author":[{"given":"A.S.","family":"Moore","sequence":"first","affiliation":[{"name":"Veterinary Oncology Consultants, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.E.","family":"Frimberger","sequence":"additional","affiliation":[{"name":"Veterinary Oncology Consultants, NSW ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.F.","family":"Moore","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology, School of Veterinary Medicine, University of California Department of Pathology, , Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,9,1]]},"reference":[{"key":"2026020304170216300_jvim986-bib-0001","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1177\/030098589803500603","article-title":"Pathologic and prognostic characteristics of splenomegaly in dogs due to fibrohistiocytic nodules: 98 cases","volume":"35","author":"Spangler","year":"1998","journal-title":"Vet Pathol"},{"key":"2026020304170216300_jvim986-bib-0002","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1354\/vp.39-1-74","article-title":"Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs","volume":"39","author":"Affolter","year":"2002","journal-title":"Vet Pathol"},{"key":"2026020304170216300_jvim986-bib-0003","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1354\/vp.43-3-241","article-title":"Canine indolent nodular lymphoma","volume":"43","author":"Valli","year":"2006","journal-title":"Vet Pathol"},{"key":"2026020304170216300_jvim986-bib-0004","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1354\/vp.43-5-632","article-title":"Canine hemophagocytic histiocytic sarcoma: A proliferative disorder of CD11d+ macrophages","volume":"43","author":"Moore","year":"2006","journal-title":"Vet Pathol"},{"key":"2026020304170216300_jvim986-bib-0005","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1177\/030098589202900410","article-title":"Six cases of malignant fibrous histiocytoma of the canine spleen","volume":"29","author":"Hendrick","year":"1992","journal-title":"Vet Pathol"},{"key":"2026020304170216300_jvim986-bib-0006","first-page":"1041","article-title":"Canine histiocytic neoplasia: An overview","volume":"48","author":"Fulmer","year":"2007","journal-title":"Can Vet J"},{"key":"2026020304170216300_jvim986-bib-0007","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1939-1676.2007.tb02937.x","article-title":"CCNU for the treatment of dogs with histiocytic sarcoma","volume":"21","author":"Skorupski","year":"2007","journal-title":"J Vet Intern Med"},{"key":"2026020304170216300_jvim986-bib-0008","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1476-5829.2009.00186.x","article-title":"Long-term survival in dogs with localized histiocytic sarcoma treated with CCNU as an adjuvant to local therapy","volume":"7","author":"Skorupski","year":"2009","journal-title":"Vet Comp Oncol"},{"key":"2026020304170216300_jvim986-bib-0009","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1111\/j.1939-1676.2010.0588.x","article-title":"Phase II, open-label trial of single-agent CCNU in dogs with previously untreated histiocytic sarcoma","volume":"24","author":"Rassnick","year":"2010","journal-title":"J Vet Intern Med"},{"key":"2026020304170216300_jvim986-bib-0010","doi-asserted-by":"crossref","first-page":"784","DOI":"10.2460\/javma.1989.195.06.784","article-title":"Mehlaff Schunk CJ. Nonangiogenic and nonlymphomatous sarcomas of the canine spleen: 57 cases (1975\u20131987)","volume":"195","author":"Weinstein","year":"1989","journal-title":"J Am Vet Med Assoc"},{"key":"2026020304170216300_jvim986-bib-0011","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1939-1676.1997.tb00085.x","article-title":"Pathologic factors affecting postsplenectomy survival in dogs","volume":"11","author":"Spangler","year":"1997","journal-title":"J Vet Intern Med"},{"key":"2026020304170216300_jvim986-bib-0012","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1748-5827.1995.tb02769.x","article-title":"A review of pathological diagnoses made from 87 canine splenic biopsies","volume":"36","author":"Day","year":"1995","journal-title":"J Small Anim Pract"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1939-1676.2012.00986.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/26\/5\/1164\/66683083\/jvim986.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/26\/5\/1164\/66683083\/jvim986.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:17:16Z","timestamp":1770110236000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/26\/5\/1164\/8451532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,1]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9,1]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1939-1676.2012.00986.x","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,9]]},"published":{"date-parts":[[2012,9,1]]}}}