{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:54:44Z","timestamp":1777301684839,"version":"3.51.4"},"reference-count":162,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Macrovascular complications are responsible for the high morbidity and mortality in patients with diabetes. Peroxisome proliferator\u2010activated receptor \u03b3 (PPAR\u03b3) plays a central role in the process of adipocyte differentiation and insulin sensitization, and also possesses anti\u2010atherogenic effects. Recently, some statins, angiotensin II type 1 receptor blockers and calcium channel blockers have been reported to activate PPAR\u03b3. However, the impact of PPAR\u03b3 activation on diabetic macrovascular complications is not fully understood. It has been reported that the activation of PPAR\u03b3 by thiazolidinediones induces anti\u2010atherogenic effects in vascular cells, including monocytes\/macrophages, endothelial cells and smooth muscle cells, in atherosclerotic animal models and in clinical studies. We have reported that hydroxymethylglutaryl coenzyme\u2003A reductase inhibitors (statins), which are used for treatment of hypercholesterolemia, activate PPAR\u03b3 and mediate anti\u2010atherogenic effects through PPAR\u03b3 activation in macrophages. Also, telmisartan, an angiotensin type I receptor blocker, has been reported to have anti\u2010atherogenic effects through PPAR\u03b3 activation. Furthermore, we have reported that nifedipine, a dihydropyridine calcium channel blocker, can activate PPAR\u03b3, thereby mediating anti\u2010atherogenic effects in macrophages. Therefore, statin therapy and part of anti\u2010hypertensive therapy might produce beneficial effects through PPAR\u03b3 activation in hypercholesterolemic and\/or hypertensive patients with diabetes, and PPAR\u03b3 might be a therapeutic target for diabetic macrovascular complications. In the present review, we focus on the anti\u2010atherogenic effects of PPAR\u03b3 and suggest potential therapeutic approaches to prevent diabetic macrovascular complications.<jats:bold>(J Diabetes Invest, doi: 10.1111\/j.2040\u20101124.2011.00182.x, 2012)<\/jats:bold><\/jats:p>","DOI":"10.1111\/j.2040-1124.2011.00182.x","type":"journal-article","created":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T19:44:52Z","timestamp":1322855092000},"page":"11-23","source":"Crossref","is-referenced-by-count":3,"title":["Thiazolidinedione\u2010independent activation of peroxisome proliferator\u2010activated receptor \u03b3 is a potential target for diabetic macrovascular complications"],"prefix":"10.1111","volume":"3","author":[{"given":"Takeshi","family":"Matsumura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayo","family":"Taketa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiya","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03410230074031"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.7.1138"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807233390404"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03290450033020"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114266"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199912)41:4<540::AID-NEU9>3.0.CO;2-P"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb01003.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(95)01064-K"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.09.015"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-1_Part_2-199601011-00009"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.7.1167"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7258.405"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7134.823"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.4.614"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13636-7"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610033351401"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.16.1893"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12948-0"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16895-5"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.03.067"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)04311-6"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7160.713"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.12.2091"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08089-3"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903043400902"},{"key":"e_1_2_8_27_2","first-page":"457","article-title":"Peroxisome proliferator\u2010activated receptor \u03b3: a key regulator of adipogenesis and systemic insulin sensitivity","volume":"2","author":"Spiegelman BM","year":"1997","journal-title":"Eur J Med Res"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90194-9"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.20.5.649"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90193-0"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/22572"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81574-3"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408384102"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.341"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2005.12.002"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.41.26652"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/34178"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.03.033"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.02.013"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2004.11.010"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609149200"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.15.7355"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.135.2.8033830"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.1.8536636"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65577-0"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.5.394"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.11.1097"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65540-X"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.13.7614"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10370"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18730"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.3.365"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.3.372"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.041609298"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67528-9"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.21.joc60158"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.13.1561"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-0699"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072761"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.10.1189"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.7.1547"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000179226.34112.6d"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.9.2094"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.3.235"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.6.516"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000044461.01844.C9"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.05.009"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M910452199"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.11.1311"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118991"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00758-5"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3001.092040"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.15.1834"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.6.1232"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.7.3125"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00062.2002"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81575-5"},{"key":"e_1_2_8_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32377-4"},{"key":"e_1_2_8_79_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.5.1333"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00164-2"},{"key":"e_1_2_8_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/83348"},{"key":"e_1_2_8_82_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8119"},{"key":"e_1_2_8_83_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200006000-00005"},{"key":"e_1_2_8_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05894"},{"key":"e_1_2_8_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.06.010"},{"key":"e_1_2_8_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/34184"},{"key":"e_1_2_8_87_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1968"},{"key":"e_1_2_8_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00461-1"},{"key":"e_1_2_8_89_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.12.4600"},{"key":"e_1_2_8_90_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.10.5.680"},{"key":"e_1_2_8_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(91)90260-A"},{"key":"e_1_2_8_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)31712-5"},{"key":"e_1_2_8_93_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.11.3013"},{"key":"e_1_2_8_94_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.9.4915"},{"key":"e_1_2_8_95_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.1.98"},{"key":"e_1_2_8_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.04.022"},{"key":"e_1_2_8_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03988"},{"key":"e_1_2_8_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.06.029"},{"key":"e_1_2_8_99_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.3.335"},{"key":"e_1_2_8_100_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.6.1781"},{"key":"e_1_2_8_101_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199502233320807"},{"key":"e_1_2_8_102_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199856001-00002"},{"key":"e_1_2_8_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00525-2"},{"key":"e_1_2_8_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.03.002"},{"key":"e_1_2_8_105_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-S011"},{"key":"e_1_2_8_106_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.20.1643"},{"key":"e_1_2_8_107_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199912000-00010"},{"key":"e_1_2_8_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(99)00045-5"},{"key":"e_1_2_8_109_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.1.3"},{"key":"e_1_2_8_110_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.21.8.1256"},{"key":"e_1_2_8_111_2","doi-asserted-by":"publisher","DOI":"10.1161\/hq1101.098486"},{"key":"e_1_2_8_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00146-2"},{"key":"e_1_2_8_113_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02684000"},{"key":"e_1_2_8_114_2","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2001.0922"},{"key":"e_1_2_8_115_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000268411.49545.9c"},{"key":"e_1_2_8_116_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104197200"},{"key":"e_1_2_8_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.05.039"},{"key":"e_1_2_8_118_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119812"},{"key":"e_1_2_8_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.10.015"},{"key":"e_1_2_8_120_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502761200"},{"key":"e_1_2_8_121_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.13.1586"},{"key":"e_1_2_8_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00239-4"},{"key":"e_1_2_8_123_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200302000-00028"},{"key":"e_1_2_8_124_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200109000-00008"},{"key":"e_1_2_8_125_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000123072.34629.57"},{"key":"e_1_2_8_126_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000127955.36250.65"},{"key":"e_1_2_8_127_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.222067"},{"key":"e_1_2_8_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.08.009"},{"key":"e_1_2_8_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.10.037"},{"key":"e_1_2_8_130_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-009-0051-1"},{"key":"e_1_2_8_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2010.09.014"},{"key":"e_1_2_8_132_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282f52c36"},{"key":"e_1_2_8_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.08.043"},{"key":"e_1_2_8_134_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833a551a"},{"key":"e_1_2_8_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.09.013"},{"key":"e_1_2_8_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.06.023"},{"key":"e_1_2_8_137_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.416"},{"key":"e_1_2_8_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.12.036"},{"key":"e_1_2_8_139_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.138750"},{"key":"e_1_2_8_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.07.014"},{"key":"e_1_2_8_141_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.14.133"},{"key":"e_1_2_8_142_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.13.1503"},{"key":"e_1_2_8_143_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039288.86470.DD"},{"key":"e_1_2_8_144_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110384"},{"key":"e_1_2_8_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(90)90091-V"},{"key":"e_1_2_8_146_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.5.3.250"},{"key":"e_1_2_8_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91121-P"},{"key":"e_1_2_8_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02527-7"},{"key":"e_1_2_8_149_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.6.1410"},{"key":"e_1_2_8_150_2","doi-asserted-by":"publisher","DOI":"10.2143\/AC.57.4.2005421"},{"key":"e_1_2_8_151_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000165677.71421.8c"},{"key":"e_1_2_8_152_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.202309"},{"key":"e_1_2_8_153_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.42.29796"},{"key":"e_1_2_8_154_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703730"},{"key":"e_1_2_8_155_2","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/S0022-3565(25)38153-X","article-title":"Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide","volume":"265","author":"Szab\u00f3 C","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_156_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0467"},{"key":"e_1_2_8_157_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00849-3"},{"key":"e_1_2_8_158_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000198031.30095.d1"},{"key":"e_1_2_8_159_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000117178.94087.ba"},{"key":"e_1_2_8_160_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.4556"},{"key":"e_1_2_8_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.05.061"},{"key":"e_1_2_8_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.06.093"},{"key":"e_1_2_8_163_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1068"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.2040-1124.2011.00182.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.2040-1124.2011.00182.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T19:21:26Z","timestamp":1741980086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.2040-1124.2011.00182.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":162,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1111\/j.2040-1124.2011.00182.x"],"URL":"https:\/\/doi.org\/10.1111\/j.2040-1124.2011.00182.x","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}