{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T13:13:25Z","timestamp":1700658805964},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T00:00:00Z","timestamp":1346976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Liraglutide, a glucagon\u2010like peptide\u20101 receptor agonist, is expected to provide a new treatment option for diabetes. However, the suitable timing of liraglutide administration in type\u00a02 diabetic patients has not yet been clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We reviewed type\u00a02 diabetic patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0155) who visited the <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>saka <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ed <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ross <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital for glycemic control, with administration of liraglutide at a dose of 0.6\u00a0mg (average glycated hemoglobin [<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content><jats:sub>1c<\/jats:sub>] level, 8.7\u00a0\u00b1\u00a00.1%). The effect of liraglutide based on the pretreatment status was compared. We also analyzed the background factors of both a successful and failed group of patients who switched to liraglutide from insulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An improvement in blood glucose levels was confirmed in 122 of 155 patients. During the 4\u2010month observation period, the improvement in <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content><jats:sub>1c<\/jats:sub> levels was significantly greater in the group of drug\u2010na\u00efve\/previous oral hypoglycemic agent (9.1\u00a0\u00b1\u00a00.2 to 7.2\u00a0\u00b1\u00a00.2%) than that in the group switching from insulin (8.6\u00a0\u00b1\u00a00.2 to 7.8\u00a0\u00b1\u00a00.2%). In addition, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010peptide immunoreactivity levels (fasting &gt;\u00a02.2\u00a0ng\/mL; delta &gt;1.6\u00a0ng\/mL; urine &gt;\u00a070\u00a0\u03bcg\/day), younger age and a smaller number of insulin units used per day were considered important when deciding on switching to liraglutide from insulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liraglutide was more effective in patients who had not been treated previously or received oral hypoglycemic agents than in patients switching from insulin. With respect to switching to liraglutide from insulin, the most important factors to be considered were <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010peptide immunoreactivity levels, age, and the number of insulin units used per day.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.2040-1124.2012.00242.x","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T13:46:12Z","timestamp":1347025572000},"page":"69-77","source":"Crossref","is-referenced-by-count":8,"title":["Liraglutide administration in type\u00a02 diabetic patients who either received no previous treatment or were treated with an oral hypoglycemic agent showed greater efficacy than that in patients switching from insulin"],"prefix":"10.1111","volume":"4","author":[{"given":"Takuo","family":"Nambu","sequence":"first","affiliation":[{"name":"Department of Diabetes Mellitus and Endocrinology Osaka Red Cross Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Diabetes Mellitus and Endocrinology Osaka Red Cross Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Diabetes Mellitus and Endocrinology Osaka Red Cross Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yugo","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Diabetes Mellitus and Endocrinology Osaka Red Cross Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Yonemitsu","sequence":"additional","affiliation":[{"name":"Department of Diabetes Mellitus and Endocrinology Osaka Red Cross Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Muro","sequence":"additional","affiliation":[{"name":"Department of Diabetes Mellitus and Endocrinology Osaka Red Cross Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Oki","sequence":"additional","affiliation":[{"name":"Department of Diabetes Mellitus and Endocrinology Osaka Red Cross Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1149-y"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1882"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2069-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.01.046"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.00887.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.158"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2007.08.021"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02666.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1355"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61246-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-2124"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1472-y"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60659-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0101"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007991003672551"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2011.00128.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2009.01194.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2011.00103.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(11)70023-7"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.03.015"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1169-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(02)00177-8"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.11.3317"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1630"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2006.00686.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp068177"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2005.06.013"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2.424"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-0174"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.12.4.388"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0855-1"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2532"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1592"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2008.03.018"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1335"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.2040-1124.2012.00242.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.2040-1124.2012.00242.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T12:54:43Z","timestamp":1700657683000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.2040-1124.2012.00242.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,7]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/j.2040-1124.2012.00242.x"],"URL":"https:\/\/doi.org\/10.1111\/j.2040-1124.2012.00242.x","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,7]]}}}