{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:26:20Z","timestamp":1789943180793,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1979,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1111\/j.2041-1014.2010.00566.x","type":"journal-article","created":{"date-parts":[[2010,3,11]],"date-time":"2010-03-11T09:30:25Z","timestamp":1268299825000},"page":"102-111","source":"Crossref","is-referenced-by-count":13,"title":["Synergistic effects of lipopolysaccharides from periodontopathic bacteria on pro-inflammatory cytokine production in an<i>ex vivo<\/i>whole blood model"],"prefix":"10.1111","volume":"25","author":[{"given":"C.","family":"Bodet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Grenier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4049\/jimmunol.160.1.403","article-title":"IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis","volume":"160","author":"Assuma","year":"1998","journal-title":"J Immunol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1600-0765.1970.tb01836.x","article-title":"Presence of leukocytes in crevices of healthy and chronically inflamed gingivae","volume":"5","author":"Attstrom","year":"1970","journal-title":"J Periodontal Res"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.micinf.2005.05.015","article-title":"Inflammatory responses of a macrophage\/epithelial cell co-culture model to mono and mixed infections with Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia","volume":"8","author":"Bodet","year":"2006","journal-title":"Microbes Infect"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.patbio.2006.07.045","article-title":"Pathogenic potential of Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, the red bacterial complex associated with periodontitis","volume":"55","author":"Bodet","year":"2007","journal-title":"Pathol Biol (Paris)"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1600-0765.2006.00938.x","article-title":"Identification of intracellular oral species within human crevicular epithelial cells from subjects with chronic periodontitis by fluorescence in situ hybridization","volume":"42","author":"Colombo","year":"2007","journal-title":"J Periodontal Res"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB6","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1128\/JB.155.2.831-838.1983","article-title":"Procedure for isolation of bacterial lipopolysaccharides from both smooth and rough Pseudomonas aeruginosa and Salmonella typhimurium strains","volume":"155","author":"Darveau","year":"1983","journal-title":"J Bacteriol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1034\/j.1600-0765.2003.02012.x","article-title":"Patterns of chemokines and chemokine receptors expression in different forms of human periodontal disease","volume":"38","author":"Garlet","year":"2003","journal-title":"J Periodontal Res"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1902\/jop.2003.74.3.391","article-title":"The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction","volume":"74","author":"Graves","year":"2003","journal-title":"J Periodontol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1399-302X.1992.tb00589.x","article-title":"Demonstration of a bimodal coaggregation reaction between Porphyromonas gingivalis and Treponema denticola","volume":"7","author":"Grenier","year":"1992","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB10","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.1128\/IAI.60.12.5298-5301.1992","article-title":"Nutritional interactions between two suspected periodontopathogens, Treponema denticola and Porphyromonas gingivalis","volume":"60","author":"Grenier","year":"1992","journal-title":"Infect Immun"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB11","first-page":"275","volume-title":"Oral Bacterial Ecology: The Molecular Basis","author":"Grenier","year":"2000"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0757.1994.tb00020.x","article-title":"Microbial etiological agents of destructive periodontal diseases","volume":"5","author":"Haffajee","year":"1994","journal-title":"Periodontol 2000"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0378-1097(03)00615-3","article-title":"Binding of Porphyromonas gingivalis fimbriae to Treponema denticola dentilisin","volume":"226","author":"Hashimoto","year":"2003","journal-title":"FEMS Microbiol Lett"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0757.1993.tb00230.x","article-title":"Tissues and cells of the periodontium","volume":"3","author":"Hassell","year":"1993","journal-title":"Periodontol 2000"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00784-001-0134-3","article-title":"Immunohistological and morphometric analysis of inflammatory cells in rapidly progressive periodontitis and adult periodontitis","volume":"5","author":"Hillmann","year":"2001","journal-title":"Clin Oral Investig"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0757.2005.00113.x","article-title":"Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the \u201cred complex\u201d, a prototype polybacterial pathogenic consortium in periodontitis","volume":"38","author":"Holt","year":"2005","journal-title":"Periodontol 2000"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1099\/mic.0.25791-0","article-title":"Molecular analysis of bacteria in periodontitis: evaluation of clone libraries, novel phylotypes and putative pathogens","volume":"149","author":"Hutter","year":"2003","journal-title":"Microbiology"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2209\/tdcpublication.41.109","article-title":"Significance of detection of Porphyromonas gingivalis, Bacteroides forsythus and Treponema denticola in periodontal pockets","volume":"41","author":"Kasuga","year":"2000","journal-title":"Bull Tokyo Dent Coll"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1399-302X.1998.tb00694.x","article-title":"Virulence of a polymicrobic complex, Treponema denticola and Porphyromonas gingivalis, in a murine model","volume":"13","author":"Kesavalu","year":"1998","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB20","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1128\/IAI.00733-06","article-title":"Rat model of polymicrobial infection, immunity, and alveolar bone resorption in periodontal disease","volume":"75","author":"Kesavalu","year":"2007","journal-title":"Infect Immun"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB21","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.micinf.2003.09.015","article-title":"Mixed infections with Porphyromonas gingivalis and Treponema denticola cause excessive inflammatory responses in a mouse pneumonia model compared with monoinfections","volume":"5","author":"Kimizuka","year":"2003","journal-title":"Microbes Infect"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1600-0757.1997.tb00191.x","article-title":"The host response to the microbial challenge in periodontitis: assembling the players","volume":"14","author":"Kornman","year":"1997","journal-title":"Periodontol 2000"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-0765.1980.tb00269.x","article-title":"Sulcular polymorphonuclear leucocytes and gingival exudate during experimental gingivitis in man","volume":"15","author":"Kowashi","year":"1980","journal-title":"J Periodontal Res"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB24","doi-asserted-by":"crossref","first-page":"14547","DOI":"10.1073\/pnas.96.25.14547","article-title":"Bacterial diversity within the human subgingival crevice","volume":"96","author":"Kroes","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB25","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.0902-0055.2004.00135.x","article-title":"Quantitative detection of periodontal pathogens using real-time polymerase chain reaction with TaqMan probes","volume":"19","author":"Kuboniwa","year":"2004","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB26","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1902\/jop.2005.76.11-S.2047","article-title":"Biofilm formation by the periodontopathic bacteria Treponema denticola and Porphyromonas gingivalis","volume":"76","author":"Kuramitsu","year":"2005","journal-title":"J Periodontol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB27","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1902\/jop.2005.76.11.1849","article-title":"Gingival crevicular fluid levels of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha in patients with chronic and aggressive periodontitis","volume":"76","author":"Kurtis","year":"2005","journal-title":"J Periodontol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB28","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S1607-551X(09)70484-X","article-title":"Potential role of vascular endothelial growth factor, interleukin-8 and monocyte chemoattractant protein-1 in periodontal diseases","volume":"19","author":"Lee","year":"2003","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB29","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1128\/JCM.12.6.792-795.1980","article-title":"Rifampin as a selective agent for isolation of oral spirochetes","volume":"12","author":"Leschine","year":"1980","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB30","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1902\/jop.2004.75.5.717","article-title":"Subgingival microbiota of Chilean patients with chronic periodontitis","volume":"75","author":"Lopez","year":"2004","journal-title":"J Periodontol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB31","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1177\/00220345010800101301","article-title":"The localization of periodontal-disease-associated bacteria in human periodontal pockets","volume":"80","author":"Noiri","year":"2001","journal-title":"J Dent Res"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.0906-6713.2004.003559.x","article-title":"Antigens of bacteria associated with periodontitis","volume":"35","author":"O\u2019Brien-Simpson","year":"2004","journal-title":"Periodontol 2000"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB33","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/10454411980090030101","article-title":"Cytokine expression in periodontal health and disease","volume":"9","author":"Okada","year":"1998","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB34","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1128\/JB.183.12.3770-3783.2001","article-title":"Bacterial diversity in human subgingival plaque","volume":"183","author":"Paster","year":"2001","journal-title":"J Bacteriol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB35","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1601-0825.2004.01021.x","article-title":"Intracellular localization of Porphyromonas gingivalis thiol proteinase in periodontal tissues of chronic periodontitis patients","volume":"10","author":"Rautemaa","year":"2004","journal-title":"Oral Dis"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB36","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1074-7613(00)80334-9","article-title":"Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment","volume":"6","author":"Romano","year":"1997","journal-title":"Immunity"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/154405910508400110","article-title":"Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythensis are components of a polymicrobial intracellular flora within human buccal cells","volume":"84","author":"Rudney","year":"2005","journal-title":"J Dent Res"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB38","doi-asserted-by":"crossref","first-page":"15661","DOI":"10.1074\/jbc.273.25.15661","article-title":"Evidence for a new type of outer membrane lipid in oral spirochete Treponema denticola. Functioning permeation barrier without lipopolysaccharides","volume":"273","author":"Schultz","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB39","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB40","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1902\/jop.1991.62.8.504","article-title":"Tissue levels of bone resorptive cytokines in periodontal disease","volume":"62","author":"Stashenko","year":"1991","journal-title":"J Periodontol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB41","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1902\/jop.1994.65.2.147","article-title":"Assessment of interleukin-6 in the pathogenesis of periodontal disease","volume":"65","author":"Takahashi","year":"1994","journal-title":"J Periodontol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB42","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1128\/JCM.35.6.1378-1381.1997","article-title":"Characterization of Bacteroides forsythus isolates","volume":"35","author":"Takemoto","year":"1997","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB43","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.femsle.2005.07.019","article-title":"Synergistic biofilm formation by Treponema denticola and Porphyromonas gingivalis","volume":"250","author":"Yamada","year":"2005","journal-title":"FEMS Microbiol Lett"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB44","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1902\/jop.1991.62.12.737","article-title":"The histological investigation of gingiva from patients with chronic renal failure, renal transplants, and periodontitis: a light and electron microscopic study","volume":"62","author":"Yamalik","year":"1991","journal-title":"J Periodontol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1399-302X.1996.tb00334.x","article-title":"Interbacterial binding among strains of pathogenic and commensal oral bacterial species","volume":"11","author":"Yao","year":"1996","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB46","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1034\/j.1600-0765.2001.036004237.x","article-title":"Mixed infection of Porphyromonas gingivalis and Bacteroides forsythus in a murine abscess model: involvement of gingipains in a synergistic effect","volume":"36","author":"Yoneda","year":"2001","journal-title":"J Periodontal Res"},{"key":"10.1111\/j.2041-1014.2010.00566.x-BIB47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1600-0765.2005.00774.x","article-title":"Stimulation of growth of Porphyromonas gingivalis by cell extracts from Tannerella forsythia","volume":"40","author":"Yoneda","year":"2005","journal-title":"J Periodontal Res"}],"container-title":["Molecular Oral Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.2041-1014.2010.00566.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.2041-1014.2010.00566.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T23:30:54Z","timestamp":1685489454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.2041-1014.2010.00566.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,4]]}},"URL":"https:\/\/doi.org\/10.1111\/j.2041-1014.2010.00566.x","relation":{},"ISSN":["2041-1006","2041-1014"],"issn-type":[{"value":"2041-1006","type":"print"},{"value":"2041-1014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}