{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:59:54Z","timestamp":1789207194381,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,1,10]],"date-time":"2011-01-10T00:00:00Z","timestamp":1294617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p> <jats:italic>Streptococcus anginosus<\/jats:italic>, an anginosus group bacterium, is frequently isolated from odontogenic abscesses, and is the oral bacterium that is primarily responsible for producing hydrogen sulfide from <jats:sc>l<\/jats:sc>\u2010cysteine through the action of its <jats:sc>l<\/jats:sc>\u2010cysteine desulfhydrase (\u03b2C\u2010S lyase) enzyme. However, the relationship between its production of hydrogen sulfide and abscess formation has not been investigated. To elucidate the etiological role of hydrogen sulfide in abscess formation, we initially measured, using specific primers, expression of the <jats:italic>lcd<\/jats:italic> gene, which encodes \u03b2C\u2010S lyase, in the pus of abscesses that formed in BALB\/c mice following subcutaneous injection of <jats:italic>S.\u00a0anginosus<\/jats:italic> into the dorsa. Expression of <jats:italic>lcd<\/jats:italic> was &gt;15\u2010fold higher when <jats:sc>l<\/jats:sc>\u2010cysteine was present than when it was absent. A mouse virulence assay revealed that the mean diameter of abscesses caused by <jats:italic>S.\u00a0anginosus<\/jats:italic> FW73 plus <jats:sc>l<\/jats:sc>\u2010cysteine was greater than that of abscesses caused by <jats:italic>S.\u00a0anginosus<\/jats:italic> FW73 in the absence of <jats:sc>l<\/jats:sc>\u2010cysteine. These findings demonstrate that the <jats:italic>lcd<\/jats:italic> gene of <jats:italic>S.\u00a0anginosus<\/jats:italic> is upregulated in mouse abscesses and that hydrogen sulfide, the product of a reaction catalyzed by \u03b2C\u2010S lyase, plays an etiological role in odontogenic abscess formation.<\/jats:p>","DOI":"10.1111\/j.2041-1014.2010.00599.x","type":"journal-article","created":{"date-parts":[[2011,1,10]],"date-time":"2011-01-10T11:44:19Z","timestamp":1294659859000},"page":"221-227","source":"Crossref","is-referenced-by-count":17,"title":["<i>Streptococcus anginosus<\/i><scp>l<\/scp>\u2010cysteine desulfhydrase gene expression is associated with abscess formation in BALB\/c 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