{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:21:25Z","timestamp":1792740085551,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,30]],"date-time":"2011-01-30T00:00:00Z","timestamp":1296345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Oral Microbiology"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p> <jats:italic>Streptococcus sanguinis<\/jats:italic> is a major component of the oral flora and an important cause of infective endocarditis. Although <jats:italic>S.\u00a0sanguinis<\/jats:italic> is naturally competent, genome sequencing has suggested significant differences in the <jats:italic>S.\u00a0sanguinis<\/jats:italic> competence system relative to those of other streptococci. An <jats:italic>S.\u00a0sanguinis<\/jats:italic> mutant possessing an in\u2010frame deletion in the <jats:italic>comC<\/jats:italic> gene, which encodes competence\u2010stimulating peptide (CSP), was created. Addition of synthetic CSP induced competence in this strain. Gene expression in this strain was monitored by microarray analysis at multiple time\u2010points from 2.5 to 30\u2003min after CSP addition, and verified by quantitative reverse transcription\u2013polymerase chain reaction. Over 200 genes were identified whose expression was altered at least two\u2010fold in at least one time point, with the majority upregulated. The \u2018late\u2019 response was typical of that seen in previous studies. However, comparison of the \u2018early\u2019 response in <jats:italic>S.\u00a0sanguinis<\/jats:italic> with that of other oral streptococci revealed unexpected differences with regard to the number of genes induced, the nature of those genes, and their putative upstream regulatory sequences. <jats:italic>Streptococcus sanguinis<\/jats:italic> possesses a comparatively limited early response, which may define a minimal streptococcal competence regulatory circuit.<\/jats:p>","DOI":"10.1111\/j.2041-1014.2011.00606.x","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T09:06:31Z","timestamp":1296464791000},"page":"99-116","source":"Crossref","is-referenced-by-count":50,"title":["Physiological and molecular characterization of genetic competence in <i>Streptococcus 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