{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:16:06Z","timestamp":1762917366837},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T00:00:00Z","timestamp":1324252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> The aim of this retrospective study was to evaluate the outcome of medical treatment of classic trigeminal neuralgia and to assess the factors affecting the choice of drug regimen (single or multiple), and the duration of treatment for pain control.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 260 consecutive patients were included in the study. Sixty\u2010one patients with less than 6\u2003months\u2019 follow up were excluded. All patients were treated with carbamazepine alone or in combination with other drugs. The dosage was adjusted according to the level of pain control and side\u2010effects.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Treatment was terminated in 99 patients (49.7%) after a mean follow\u2010up period of 36.46\u2003months (standard deviation: \u00b126.5). Of these, 39.4% were on a single drug. Carbamazepine was the drug used in 36 patients. The rest (61%) needed various combinations of drugs. One\u2010hundred patients (50.3%) continued with medical treatment during the follow\u2010up period. Of these, 67.4% were on multi\u2010drug therapy.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The present study showed that the administration of multidrug regimens is a useful alternative in controlling trigeminal neuralgia in patients who are unable to tolerate higher doses of carbamazepine. Age, sex, ethnicity, and the side of affliction did not have a significant influence on the choice of drug regimen and the duration of treatment for pain control.<\/jats:p>","DOI":"10.1111\/j.2041-1626.2011.00109.x","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T07:41:47Z","timestamp":1324280507000},"page":"98-102","source":"Crossref","is-referenced-by-count":5,"title":["Use of single\u2010 and multi\u2010drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11\u2010year experience at a single Sri Lankan institution"],"prefix":"10.1111","volume":"3","author":[{"given":"Anura","family":"Ariyawardana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjith","family":"Pallegama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohaideen","family":"Sitheeque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajith","family":"Ranasinghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,19]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"Classification of chronic pain. 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